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Source: Clinical Cardiology
Condition: Bleeding
Education: Study

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Total 19 results found since Jan 2013.

Sex ‐Differences in Post‐Discharge Outcomes Among Patients Hospitalized for Atrial Fibrillation
ConclusionsHospitalization for AF is common and frequently associated with both in ‐hospital complications and re‐admission, which were more commonly observed among women with AF. Further research into epidemiological factors and treatment differences between men and women with AF is warranted.
Source: Clinical Cardiology - November 12, 2018 Category: Cardiology Authors: Bindu Kalesan, Amartya Kundu, Aditya Vaze, Elizabeth Pino, Allan J. Walkey, Ramachandran S Vasan, David D. McManus Tags: CLINICAL INVESTIGATIONS Source Type: research

Rationale, design and preliminary results of the Quebec Warfarin Cohort Study
ConclusionsThe QWC represents a good research opportunity to investigate clinical and genetic factors in a warfarin anticoagulated population.
Source: Clinical Cardiology - March 15, 2018 Category: Cardiology Authors: Sylvie Perreault, Payman Shahabi, Robert C ôté, Stéphanie Dumas, Étienne Rouleau‐Mailloux, Yassamin Feroz Zada, Sylvie Provost, Ian Mongrain, Marc Dorais, Thao Huynh, Simon Kouz, Ariel Diaz, Mark Blostein, Simon de Denus, Jacques Turgeon, Jeffrey Gi Tags: TRIAL DESIGNS Source Type: research

Incidence of thromboembolic and bleeding events in patients with newly diagnosed nonvalvular atrial fibrillation: An Asian multicenter retrospective cohort study in Singapore
ConclusionsSAPT and DAPT are less effective than warfarin in NVAF patients. DOACs may be considered in view of lower risk of overall bleed.
Source: Clinical Cardiology - November 1, 2017 Category: Cardiology Authors: Xue Ting Wee, Lih Maan Ho, Han Kiat Ho, Joyce Yu ‐Chia Lee, Chun Wei Yap, Henry William, Linus Chong En Chan, Hooi Ching Tay, Cynthia Eei Mei Goh, Doreen Su‐Yin Tan Tags: CLINICAL INVESTIGATIONS Source Type: research

Thromboembolic risk and effect of oral anticoagulation according to atrial fibrillation patterns: A systematic review and meta ‐analysis
The objectives of the meta‐analysis were to investigate different impact on outcomes of pxAF and non‐pxAF, with and without OAC. Two reviewers searched for prospective studies on risk of stroke and systemic embolism (SE) in pxAF and non‐pxAF, with and without OAC. Quality of evidence was assessed according to GRADE approach. Stroke combined with SE was the main outcome. Meta‐regression was performed to evaluate OAC effect on stroke and SE incidence rate. We identified 18 studies. For a total of 239 528 patient‐years of follow‐up. The incidence rate of stroke/SE was 1.6% (95% confidence interval [CI]: 1.3%‐2...
Source: Clinical Cardiology - April 1, 2017 Category: Cardiology Authors: Alessio Lilli, Andrea Di Cori, Valerio Zac à Tags: REVIEWS Source Type: research

Intracardiac echocardiography for verification for left atrial appendage thrombus presence detected by transesophageal echocardiography: the ActionICE II study
ConclusionsWith TEE, a false positive of an LAA thrombus may be indicated, especially when a thrombus is described as soft rather than solid. Our study suggests that ICE may be a valuable option for verification of a TEE‐based diagnosis of a thrombus.
Source: Clinical Cardiology - February 12, 2017 Category: Cardiology Authors: Jakub Baran, Beata Zaborska, Roman Piotrowski, Malgorzata Sikora ‐Frąc, Ewa Pilichowska‐Paszkiet, Piotr Kułakowski Tags: CLINICAL INVESTIGATIONS Source Type: research

Design and Rationale of the RE ‐DUAL PCI Trial: A Prospective, Randomized, Phase 3b Study Comparing the Safety and Efficacy of Dual Antithrombotic Therapy With Dabigatran Etexilate Versus Warfarin Triple Therapy in Patients With Nonvalvular Atrial Fibrillation Who Have Undergone Percutaneous Coronary Intervention With Stenting
Antithrombotic management of patients with atrial fibrillation (AF) undergoing coronary stenting is complicated by the need for anticoagulant therapy for stroke prevention and dual antiplatelet therapy for prevention of stent thrombosis and coronary events. Triple antithrombotic therapy, typically comprising warfarin, aspirin, and clopidogrel, is associated with a high risk of bleeding. A modest‐sized trial of oral anticoagulation with warfarin and clopidogrel without aspirin showed improvements in both bleeding and thrombotic events compared with triple therapy, but large trials are lacking. The RE‐DUAL PCI trial (NCT...
Source: Clinical Cardiology - July 31, 2016 Category: Cardiology Authors: Christopher P. Cannon, Savion Gropper, Deepak L. Bhatt, Stephen G. Ellis, Takeshi Kimura, Gregory Y.H. Lip, Ph. Gabriel Steg, Jurri ën M. Berg, Jenny Manassie, Jörg Kreuzer, Jon Blatchford, Joseph M. Massaro, Martina Brueckmann, Ernesto Ferreiros Ripoll Tags: Trial Designs Source Type: research

Postoperative Strokes and Intracranial Bleeds in Patients With Atrial Fibrillation: The FibStroke Study
ConclusionsPerioperative interruption of OAC is common in patients who suffer a postoperative stroke, even in patients with low‐bleeding‐risk procedures. Postoperative intracranial bleeding is frequently preceded by perioperative heparin bridging.
Source: Clinical Cardiology - April 30, 2016 Category: Cardiology Authors: Antti Palomäki, Tuomas Kiviniemi, Juha E.K. Hartikainen, Pirjo Mustonen, Antti Ylitalo, Ilpo Nuotio, Päivi Hartikainen, Jussi Jaakkola, Riho Luite, K.E. Juhani Airaksinen Tags: Clinical Investigations Source Type: research

Clinical Outcome of First‐ vs Second‐Generation DES According to DAPT Duration: Results of ARCTIC‐Generation
ABSTRACT There is an apparent benefit with extension of dual antiplatelet therapy (DAPT) beyond 1 year after implantation of drug‐eluting stents (DES). Assessment by a Double Randomization of a Conventional Antiplatelet Strategy vs a Monitoring‐Guided Strategy for Drug‐Eluting Stent Implantation, and of Treatment Interruption vs Continuation One Year After Stenting (ARCTIC)‐Generation assessed whether there is a difference of outcome between first‐ vs second‐generation DES and if there is an interaction with DAPT duration in the ARCTIC‐Interruption study. ARCTIC‐Interruption randomly allocated 1259 patients...
Source: Clinical Cardiology - February 16, 2016 Category: Cardiology Authors: Jean‐Philippe Collet, Johanne Silvain, Mathieu Kerneis, Thomas Cuisset, Nicolas Meneveau, Ziad Boueri, Olivier Barthélémy, Grégoire Rangé, Guillaume Cayla, Eric Van Belle, Simon Elhadad, Didier Carrié, Christophe Caussin, Hélène Rousseau, Pierre Tags: Clinical Trial Updates Source Type: research

The HAS‐BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta‐analysis
ABSTRACT Our objective was to compare the diagnostic accuracy between the HAS‐BLED score and any of HEMORR2HAGES, ATRIA, CHADS2, or CHA2DS2‐VASc scores in anticoagulated patients with atrial fibrillation. We systematically searched the Cochrane Library, MEDLINE, PubMed, and Embase databases for relevant studies. Data were extracted and analyzed according to predefined clinical endpoints. Eleven studies were identified. Discrimination analysis demonstrates that HAS‐BLED has no significant C‐statistic differences for bleeding risk prediction compared with ATRIA or HEMORR2HAGES, but it has significant differences comp...
Source: Clinical Cardiology - September 29, 2015 Category: Cardiology Authors: Wengen Zhu, Wenfeng He, Linjuan Guo, Xixing Wang, Kui Hong Tags: Review Source Type: research

Initial Experience With Novel Oral Anticoagulants During the First 45 Days After Left Atrial Appendage Closure With the Watchman Device
ConclusionsOur pilot study suggests that NOAC therapy within the first 45 days after interventional LAA closure is safe and effective.
Source: Clinical Cardiology - September 1, 2015 Category: Cardiology Authors: Leif I. Bösche, Faegheh Afshari, Dominik Schöne, Aydan Ewers, Andreas Mügge, Michael Gotzmann Tags: Clinical Investigations Source Type: research

Antithrombotic Regimens for Patients Taking Oral Anticoagulation After Coronary Intervention: A Meta‐analysis of 16 Clinical Trials and 9185 Patients
This study sought to compare efficacy and safety outcomes of triple therapy (OAC, aspirin, and clopidogrel) vs dual therapy (clopidogrel with aspirin or OAC) in these patients. We hypothesize OAC plus clopidogrel could be the optimal regimen for patients with indications for OAC receiving stent implantation. Medline, the Cochrane Library, and other Internet sources were searched for clinical trials comparing the efficacy and safety of triple vs dual therapy for patients taking OAC after coronary stenting. Sixteen eligible trials including 9185 patients were identified. The risks of major adverse cardiac events (odds ratio ...
Source: Clinical Cardiology - May 12, 2015 Category: Cardiology Authors: Xiao‐Fei Gao, Yan Chen, Zhong‐Guo Fan, Xiao‐Min Jiang, Zhi‐Mei Wang, Bing Li, Wen‐Xing Mao, Jun‐Jie Zhang, Shao‐Liang Chen Tags: Reviews Source Type: research

Quality of Anticoagulation With Vitamin K Antagonists
ConclusionsPatients who receive VKA to prevent stroke for AF spend less than half the time within therapeutic range.
Source: Clinical Cardiology - May 11, 2015 Category: Cardiology Authors: Vicente Bertomeu‐González, Manuel Anguita, José Moreno‐Arribas, Ángel Cequier, Javier Muñiz, Jesús Castillo‐Castillo, Juan Sanchis, Inmaculada Roldán, Francisco Marin, Vicente Bertomeu‐Martínez, Tags: Clinical Investigations Source Type: research

Characterizing Major Bleeding in Patients With Nonvalvular Atrial Fibrillation: A Pharmacovigilance Study of 27 467 Patients Taking Rivaroxaban
ConclusionsIn this large observational study, the MB rate was generally consistent with the registration trial results, and fatal bleeds were rare.
Source: Clinical Cardiology - December 1, 2014 Category: Cardiology Authors: Sally Tamayo, W. Frank Peacock, Manesh Patel, Nicholas Sicignano, Kathleen P. Hopf, Larry E. Fields, Troy Sarich, Shujian Wu, Daniel Yannicelli, Zhong Yuan Tags: Quality and Outcomes Source Type: research

Stroke and Bleeding Risk in Atrial Fibrillation: Navigating the Alphabet Soup of Risk‐Score Acronyms (CHADS2, CHA2DS2‐VASc, R2CHADS2, HAS‐BLED, ATRIA, and More)
ABSTRACT Stroke prevention is central to the management of patients with atrial fibrillation (AF). As effective stroke prophylaxis essentially requires oral anticoagulants, an understanding of the risks and benefits of oral anticoagulant therapy is needed. Although AF increases stroke risk 5‐fold, this risk is not homogeneous. Many stroke risk factors also confer an increased risk of bleeding. Various stroke and bleeding risk‐stratification schemes have been developed to help inform clinical decision‐making. These scores were derived and validated in different study cohorts, ranging from highly selected clinical‐tr...
Source: Clinical Cardiology - August 1, 2014 Category: Cardiology Authors: Mikhail S. Dzeshka, Deirdre A. Lane, Gregory Y. H. Lip Tags: Reviews Source Type: research

One‐Year Outcome of Patients With Atrial Fibrillation Undergoing Coronary Artery Stenting: An Analysis of the AFCAS Registry
ConclusionsIn this large, real‐world population of AF patients undergoing PCI‐S, TT was the antithrombotic regimen most frequently prescribed. Although several limitations need to be acknowledged, in our study the 1‐year efficacy and safety of TT, dual antiplatelet therapy, and VKA plus clopidogrel was comparable.
Source: Clinical Cardiology - January 30, 2014 Category: Cardiology Authors: Andrea Rubboli, Axel Schlitt, Tuomas Kiviniemi, Fausto Biancari, Pasi P. Karjalainen, Josè Valencia, Mika Laine, Paulus Kirchhof, Matti Niemelä, Saila Vikman, Gregory Y. H. Lip, K. E. Juhani Airaksinen, Tags: Clinical Investigations Source Type: research