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Source: International Journal of Cardiology
Condition: Bleeding
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Total 75 results found since Jan 2013.
The Ibero-American transcatheter aortic valve implantation registry with the CoreValve prosthesis. Early and long-term results
Conclusions: Transcatheter aortic valve implantation constitutes a safe and viable therapeutic option for high operative risk patients with severe aortic stenosis. Long-term prognosis is conditioned by associate comorbidities.
Source: International Journal of Cardiology - October 15, 2013 Category: Cardiology Authors: Antonio J. Muñoz-García, Raquel del Valle, Ramiro Trillo-Nouche, Jaime Elízaga, Federico Gimeno, Rosana Hernández-Antolín, Rui Teles, Vasco de Gama Ribeiro, Eduardo Molina, Ángel Cequier, Cristóbal Urbano-Carrillo, Ignacio Cruz-González, Miguel Pa Tags: Original Articles Source Type: research
Meta-analysis of stroke after transradial versus transfemoral artery catheterization
Conclusions: TR catheterization is not associated with a significant increase in stroke compared to TF catheterization.
Source: International Journal of Cardiology - August 30, 2013 Category: Cardiology Authors: Vishal G. Patel, Kimberly M. Brayton, Dharam J. Kumbhani, Subhash Banerjee, Emmanouil S. Brilakis Tags: Original Articles Source Type: research
Clopidogrel is safer than ticagrelor in regard to bleeds: A closer look at the PLATO trial
Conclusions: Clopidogrel is safer than ticagrelor in regard to bleeding. Additionally, ticagrelor's purported faster antiplatelet ‘offset’ is substantially longer than its pharmacokinetics indicate. Considering the fact that the mortality, stent thrombosis and myocardial infarction ‘benefit’ of ticagrelor have recently been challenged, and that the increase in stroke on ticagrelor has recently been shown to be worse than originally published, the decision to use ticagrelor over clopidogrel in the face of a higher risk for bleeds is not advised.
Source: International Journal of Cardiology - July 31, 2013 Category: Cardiology Authors: James J. DiNicolantonio, Fabrizio D'Ascenzo, Ales Tomek, Saurav Chatterjee, Asfandyar K. Niazi, Giuseppe Biondi-Zoccai Tags: Editorials Source Type: research
Blood pressure. The forgotten factor in previous and recent studies regarding anticoagulation in atrial fibrillation
Atrial fibrillation is an independent risk factor for stroke and thromboembolic events . For several years the anticoagulation was principally limited to vitamine K antagonists (VKA). It was an effective drug with advantages but also disadvantages like variable response and the need for periodically INR monitoring. This has led the pharmaceutical industry to the development of newer oral anticoagulants at least as effective (or more effective) as VKAs, with lower (or similar, depending the dose) risk of bleeding and a convenient dosing regiment without the need for INR monitoring. Several studies published recently like RO...
Source: International Journal of Cardiology - July 29, 2013 Category: Cardiology Authors: M.S. Kallistratos, A.J. Manolis, G. Mancia Tags: Letters to the Editor Source Type: research
Percutaneous closure of patent foramen ovale for cryptogenic stroke: A meta-analysis of randomized controlled trials
Conclusions: Currently-available randomized data do not support the use of percutaneous PFO closure for secondary stroke prevention in patients with cryptogenic stroke and PFO. An updated meta-analysis including further data from ongoing RCTs is warranted.
Source: International Journal of Cardiology - July 26, 2013 Category: Cardiology Authors: Joey S.W. Kwong, Yat-Yin Lam, Cheuk-Man Yu Tags: Original Articles Source Type: research
Low stroke risk after elective cardioversion of atrial fibrillation: An analysis of the Flec-SL trial
Conclusion: Strokes are rare in this large, prospectively followed cohort of patients undergoing cardioversion for AF and receiving antithrombotic therapy following local routine. These results support adherence to current recommendations for anticoagulation during cardioversion of AF.
Source: International Journal of Cardiology - July 22, 2013 Category: Cardiology Authors: Stavros Apostolakis, Karl Georg Haeusler, Michael Oeff, Andras Treszl, Dietrich Andresen, Martin Borggrefe, Gregory Y.H. Lip, Thomas Meinertz, Ulrich Parade, Alexander Samol, Gerhard Steinbeck, Karl Wegscheider, Günter Breithardt, Paulus Kirchhof Tags: Original Articles Source Type: research
Safety of pacemaker and implantable cardioverter–defibrillator implantation during uninterrupted warfarin treatment — The FinPAC study
Conclusion: Our randomized study demonstrates that CRM devices can be safely implanted without discontinuation of warfarin treatment.
Source: International Journal of Cardiology - July 11, 2013 Category: Cardiology Authors: K.E. Juhani Airaksinen, Petri Korkeila, Juha Lund, Antti Ylitalo, Pasi Karjalainen, Vesa Virtanen, Pekka Raatikainen, Ulla-Maija Koivisto, Juhani Koistinen Tags: Original Articles Source Type: research
Benefits and risks of long-term duration of dual antiplatelet therapy after drug-eluting stenting: A meta-analysis of randomized trials
Conclusions: This meta-analysis provides no evidence of benefits with longer DAPT duration as compared with a shorter course of therapy. It also reports significant harms with respect to major bleeding and stroke associated with prolonged DAPT use.
Source: International Journal of Cardiology - April 15, 2013 Category: Cardiology Authors: Marco Valgimigli, Seung-Jung Park, Hyo-Soo Kim, Kyung Woo Park, Duk-Woo Park, Pierluigi Tricoci, Giuseppe Ferrante Tags: Original Articles Source Type: research
Validation of contemporary stroke and bleeding risk stratification scores in non-anticoagulated Chinese patients with atrial fibrillation
Abstract: Background: Risk stratification schemes assessing stroke and thromboembolism (stroke/TE) and bleeding relating to atrial fibrillation (AF) have largely been derived and validated in Western populations. We assessed risk factors that constitute scores for assessing stroke/TE (CHADS2, CHA2DS2-VASc) and bleeding (HAS-BLED), and the predictive value of these scores in a large cohort of Chinese patients with AF.Methods and results: We studied 1034 AF patients (27.1% female, median age 75; 85.6% non-anticoagulated) with mean follow-up of 1.9years. On multivariate analysis, vascular disease was independently associated ...
Source: International Journal of Cardiology - November 19, 2012 Category: Cardiology Authors: Yutao Guo, Stavros Apostolakis, Andrew D. Blann, Haijun Wang, Xiaoning Zhao, Yu Zhang, Dexian Zhang, Jingling Ma, Yutang Wang, Gregory Y.H. Lip Tags: Original Articles Source Type: research
Avicenna's view on the prevention of thrombosis
Thrombosis is defined as “hemostasis in the wrong place”. It makes a major contribution to mortality and morbidity in a wide range of patient populations. New or recurrent strokes affect about 795,000 people in the United States each year. In a third of patients, a complication of deep venous thrombosis is caused by embolisation of the clot into the lungs . After heart attack and stroke, pulmonary embolism takes the third rank as the most common cause of death from cardiovascular disease . Venous thrombosis is a common disease with frequent recurrences. Anticoagulants can prevent its recurrence, albeit at the cost of bleeding .
Source: International Journal of Cardiology - November 12, 2012 Category: Cardiology Authors: Ashraf Al-din Gooshah Gir, Hasan Namdar, Elham Emaratkar, Esmaeil Nazem, Mohammad Bagher Minaii, Ali reza Nikbakht Nasrabadi, Rasool Choopani Tags: Letters to the Editor Source Type: research
Stroke risk and suboptimal thromboprophylaxis in Chinese patients with atrial fibrillation: Would the novel oral anticoagulants have an impact?
Abstract: Background: The risk of stroke associated with atrial fibrillation (AF) is higher in Far Eastern population than in Western population, and warfarin use suboptimal. There is uncertainty whether the novel oral anticoagulants (NOACs) would have a major impact on stroke prevention in Far Eastern populations with AF.Objectives: We investigated current antithrombotic therapy use on stroke and bleeding risk, determinants of warfarin use and performed a modeling analysis of the net clinical benefit of the NOACs (apixaban, dabigatran) in a large cohort of Chinese patients with AF.Methods: We studied 1034 Chinese patients...
Source: International Journal of Cardiology - October 24, 2012 Category: Cardiology Authors: Yutao Guo, Ron Pisters, Stavros Apostolakis, Andrew D. Blann, Haijun Wang, Xiaoning Zhao, Yu Zhang, Dexian Zhang, Jingling Ma, Yutang Wang, Gregory Y.H. Lip Tags: Original Articles Source Type: research
Pattern of atrial fibrillation and risk of outcomes: The Loire Valley Atrial Fibrillation Project
Abstract: Background: Risk of stroke and thromboembolism (TE) in patients with non-valvular atrial fibrillation (NVAF) is categorised in stroke risk stratification scores. The role of pattern of NVAF in risk prediction is unclear in contemporary ‘real world’ cohorts.Methods and results: Patients with NVAF in a four-hospital-institution between 2000 and 2010 were included. Stroke/TE event rates were calculated according to pattern of AF, i.e. paroxysmal, persistent and permanent. Risk factors were investigated by Cox regression.Among 7156 NVAF patients, 4176 (58.4%) patients with paroxysmal, 376 (5.3%) with persistent a...
Source: International Journal of Cardiology - July 16, 2012 Category: Cardiology Authors: Amitava Banerjee, Sophie Taillandier, Jonas Bjerring Olesen, Deirdre A. Lane, Benedicte Lallemand, Gregory Y.H. Lip, Laurent Fauchier Tags: Original Articles Source Type: research
Outcomes in atrial fibrillation patients on combined warfarin & antiarrhythmic therapy
Conclusions: Allowing for differences in prescribing practice, AF/AFL patients treated with W+A are at higher risk of stroke and arterial embolism, and have higher healthcare use and costs, than patients receiving W+OAAD.
Source: International Journal of Cardiology - February 15, 2012 Category: Cardiology Authors: Annie Guérin, Jay Lin, Mehul Jhaveri, Eric Q. Wu, Andrew P. Yu, Martin Cloutier, Genevieve Gauthier, Joseph S. Alpert Tags: Original Articles Source Type: research
Impact of non-steroidal anti-inflammatory drugs (NSAIDs) on cardiovascular outcomes in patients with stable atherothrombosis or multiple risk factors
Abstract: Background: We aimed to assess whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of cardiovascular (CV) events in stable patients with established atherothrombosis or multiple risk factors.Methods: We analysed the 23,728 European patients of the REACH Registry; 20,588 (86.8%) had established atherothrombotic disease and 3140 (13.2%) had multiple risk factors only. Aspirin (ASA) and/or NSAIDs use was determined at enrolment and ischemic events were recorded over two years of follow-up. cMACCE was defined as the composite of CV death, MI or stroke. Bleeding was d...
Source: International Journal of Cardiology - June 30, 2011 Category: Cardiology Authors: Olivier Barthélémy, Tobias Limbourg, Jean Philippe Collet, Farzin Beygui, Johanne Silvain, Anne Bellemain-Appaix, Guillaume Cayla, Thomas Chastre, Iris Baumgartner, Joachim Röther, Uwe Zeymer, Deepak L. Bhatt, Gabriel Steg, Gilles Montalescot, On behal Tags: Original Articles Source Type: research
