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Patient Factors Do Not Predict Thrombolysis in Stroke Mimics (P6.031)
CONCLUSIONS: Physician decision to administer thrombolysis in stroke mimic patients without clear contraindication is not associated with patient demographic or clinical factors. Our study is limited by its retrospective nature and small sample size, however continued data collection is in process.Disclosure: Dr. Gildersleeve has nothing to disclose. Dr. Pandurengan has nothing to disclose. Dr. Gonzales has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Gildersleeve, K., Pandurengan, R., Gonzales, N. Tags: Neurotherapeutics Source Type: research

Major Hemorrhagic Complications are Associated with Lower Coated-Platelet Levels in Patients with Non-Lacunar Brain Infarction (P5.127)
Conclusions: Lower levels of coated-platelets in ischemic stroke are associated with the presence of major bleeding complications in addition to the previously observed propensity to develop early hemorrhagic transformation. These findings further support a role for coated-platelets both in the balance between thrombosis and hemorrhage in stroke as well as a potential risk stratification tool. Study supported by: Department of Veterans Affairs (award 1I01CX000340).Disclosure: Dr. Prodan has received research support from the Veterans Affairs Office. Dr. Stoner has nothing to disclose. Dr. Dale has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Prodan, C., Stoner, J., Dale, G. Tags: Cerebrovascular Disease and Interventional Neurology: Biomarkers and Emerging Science Source Type: research

Assessment of hospital readmissions in stroke patient population from the Stroke Center at the University of Kentucky: as a quality measure (P5.150)
Conclusions: Our study determined etiologies for hospital readmission after initial stroke hospitalization. Urinary tract infections were found to be the most common cause for stroke readmissions. Further analysis may help to identify risks for readmission and potentially reduce readmission rates.Disclosure: Dr. Al Sawaf has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Al Sawaf, A., Lee, J. Tags: Cerebrovascular Disease and Interventional Neurology: Quality Research and Initiatives Source Type: research

Protocol Driven Stroke Ward And Stroke Registry Results In Increased Rate Of Thrombolysis In Acute Stroke Care (P4.311)
Conclusion: Protocol-based Multidisciplinary care through Stroke ward & Stroke registry helps in improvement of AS care. It can lead to increase in thrombolysis rate, reduces related complications, improves prognosis, & increases awareness about stroke care not only in physicians & nurses but also in patients and their families.Disclosure: Dr. Akhtar has nothing to disclose. Dr. Kamran has nothing to disclose. Dr. Joseph has nothing to disclose. Dr. SANTOS has nothing to disclose. Dr. BOURKE has nothing to disclose. Dr. D'SOUZA has nothing to disclose. Dr. Imam has nothing to disclose. Dr. Shuaib has received r...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Akhtar, N., Kamran, S., Joseph, S., Santos, M., Bourke, P., D'Souza, A., Imam, Y., Shuaib, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke, Prehospital, and Telemedicine Source Type: research

An electronic decision support tool for Stroke Prevention in Atrial Fibrillation (SPAF): An integrated primary-tertiary care model of care. (S47.001)
CONCLUSIONS: Given that the existing technology base is well established nationwide, it is expected that this could become a national model which would have significant benefits for patient care and healthcare costs across the country.Disclosure: Dr. Jolliffe has nothing to disclose. Dr. Rosemergy has nothing to disclose. Dr. Lanford has nothing to disclose. Dr. Abernethy has nothing to disclose. Dr. Ranta has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Jolliffe, E., Rosemergy, I., Lanford, J., Abernethy, D., Ranta, A. Tags: Cerebrovascular Disease and Interventional Neurology Source Type: research

Incidence of ischemic or hemorrhagic non-fatal strokes in hemophiliac adults and teenage children (P7.127)
Conclusions: The rate of stroke appears to be low in adults and teenage children in a cohort of hemophiliacs with predominantly moderate and severe disease.Disclosure: Dr. Bezzina has nothing to disclose. Dr. Malik has nothing to disclose. Dr. QURESHI has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Bezzina, C., Malik, A., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

IV thrombolysis for acute cervical Internal Carotid Artery Occlusion (P6.237)
Conclusions: Intravenous thrombolysis should be rapidly administered as first-line treatment in patients with early acute cervical ICA occlusion. Recanalization is improved in patients with better collateral circulation and may be a valuable biomarker for treatment decisions.Disclosure: Dr. Kong has nothing to disclose. Dr. Teoh has nothing to disclose. Dr. Seet has nothing to disclose. Dr. Chan has nothing to disclose. Dr. Rathakrishnan has nothing to disclose. Dr. Soon has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Yeo has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kong, W. Y., Tan, B., Teoh, H. L., Seet, R., Chan, B., Rathakrishnan, R., Soon, D., Sharma, V., Sharma, V., Yeo, L. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Thrombolysis Source Type: research

Neuroimaging findings of post-thrombolysis cerebral hemorrhage in acute ischemic stroke (P6.238)
Conclusion: The most common pattern of hemorrhage observed after IV-tPA in acute ischemic stroke was petechial hemorrhagic transformation of ischemic infarct, which is most suggestive of bleeding due to blood-brain breakdown at the site of infarction. Unusual patterns of hemorrhage (such as multiplicity and remote ICH) are rare. Further studies are warranted to better understand the underlying mechanisms of hemorrhagic complications after thrombolysis.Disclosure: Dr. Lee has nothing to disclose. Dr. Cutting has nothing to disclose. Dr. Song has nothing to disclose. Dr. Cherian has nothing to disclose. Dr. Conners has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lee, V., Cutting, S., Song, S., Cherian, L., Conners, J. Tags: Cerebrovascular Disease and Interventional Neurology: Thrombolysis Complications Source Type: research

Prior Asymptomatic Intraparenchymal Hemorrhage Does Not Increase the Risk for Intracranial Hemorrhage after Intravenous Thrombolysis (P6.239)
CONCLUSIONS: In comparison with the rate of symptomatic ICH reported in the NINDS trial (6.4[percnt]), patients with a history of asymptomatic intraparenchymal hemorrhage that presented with an acute ischemic stroke did not show an increased risk of developing symptomatic intracranial hemorrhage after IV thrombolysis (p<0.001).Disclosure: Dr. AbdelRazek has nothing to disclose. Dr. Mowla has nothing to disclose. Dr. Zimmer has nothing to disclose. Dr. Elsadek has nothing to disclose. Dr. Abdelhamid has nothing to disclose. Dr. Elsadek has nothing to disclose. Dr. Kavak has nothing to disclose. Dr. Farooq has nothing to ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: AbdelRazek, M., Mowla, A., Zimmer, W., Elsadek, R., Abdelhamid, N., Elsadek, L., Kavak, K., Farooq, S., Kamal, H., Crumlish, A., Shirani, P., Sawyer, R. Tags: Cerebrovascular Disease and Interventional Neurology: Thrombolysis Complications Source Type: research

Knowledge Regarding Oral Anticoagulation Therapy among Patients with Stroke and Those at High Risk of Thromboembolic Events (P6.241)
Conclusion- Patient’s knowledge about OAT was suboptimal. The findings support the need for educational interventions to improve the knowledge regarding oral anticoagulation therapy, and thereby achieve an appropriate and safe secondary prevention of stroke.Disclosure: Dr. Bhatia has nothing to disclose. Dr. Alphonsa has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Sharma has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Bhatia, R., Alphonsa, A., Sharma, K., Sharma, G. Tags: Cerebrovascular Disease and Interventional Neurology: Thrombolysis Complications Source Type: research

Pearls & Oy-sters: Cerebral venous air embolism after central catheter removal: Too much air can kill
A 95-year-old woman with a history of hypertension presented from a long-term care facility for altered mental status in the context of dehydration and hypoglycemia. Multiple attempts to obtain a peripheral IV failed, and a triple lumen catheter was placed into the right internal jugular vein using the Seldinger technique under ultrasound guidance. No complications followed the procedure. The patient was then rehydrated and given multiple ampules of D50, leading to prompt resolution of the hypoglycemia and improvement in her mental status. After resolution of symptoms, the central line was removed, with the head of the bed...
Source: Neurology - March 30, 2015 Category: Neurology Authors: Bartolini, L., Burger, K. Tags: MRI, All Clinical Neurology, All Cerebrovascular disease/Stroke, Embolism RESIDENT AND FELLOW SECTION Source Type: research

Use of Apixaban and Warfarin in Patients Undergoing Procedures: Insights from ARISTOTLE (P5.002)
CONCLUSIONS: Procedures are common in patients with atrial fibrillation. The majority of procedures are non-major and non-emergent, and anticoagulation therapy is likely to be stopped peri-procedure. Overall and among emergent procedures, rates of clinical events in the first 30 days post-procedure were low and comparable between treatment groups.Study Supported by: Bristol-Myers Squibb Company and Pfizer Inc. Editorial assistance (i.e., formatting the abstract to ensure compliance with AAN guidelines) was provided by Claire Hall of Caudex Medical and was funded by Bristol-Myers Squibb Company and Pfizer Inc.Disclosure: Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Lopes, R., Garcia, D., Wojdyla, D., Dorian, P., Alexander, J., Wallentin, L., Lanas, F., Hanna, M., Held, C., Granger, C. Tags: Cerebrovascular Disease and Interventional Neurology II Source Type: research

Vitreous Hemorrhage as a Complication of IV-tPA Therapy in a Patient with Acute Stroke (P4.227)
CONCLUSIONS: To our knowledge, this is the first case report of vitreous hemorrhage following acute stroke therapy with IV-tPA. This underscores the risk of intraocular hemorrhage in patients with retinal neovascularization that could occur with other retinal vascular disorders such as diabetic retinopathy. The decision to proceed with IV-tPA in the presence of retinal neovascularization should be made on a case-by-case basis and further discussion with the patient.Disclosure: Dr. Shah has nothing to disclose. Dr. Verstraeten has nothing to disclose. Dr. Wright has nothing to disclose. Dr. Rana has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shah, L., Verstraeten, T., Wright, D., Rana, S. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Systemic Inflammation Exacerbates Stroke in Patients with Left Ventricular Assist Device (P4.235)
CONCLUSIONS:In LVAD patients, total prevention of cerebrovascular complications cannot be accomplished only by adjusting warfarin dosage to meet the therapeutic range. However, recognition of increased CRP and appropriate management of inflammation prior to the stroke onset may enable us to avoid its aggravation and secure patient’s opportunity for heart transplantation.Disclosure: Dr. Ohtomo has nothing to disclose. Dr. Iwata has received personal compensation for activities with Janssen Pharmaceuticals, Eisai Inc., Daiichi Pharmaceutical Corp., Ono Pharmaceutical, and Takeda Pharmaceutical Co. Ltd. Dr. Iwata has re...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ohtomo, R., Iwata, A., Kinoshita, O., Shimizu, J., Ono, M., Tsuji, S. Tags: Cerebrovascular Disease and Interventional Neurology: Cardiac Source Type: research

Collateral Circulation Recruitment and Failure in Acute Ischemic Stroke Patients Treated with IV rTPA. (P3.102)
Conclusion: substantial recruitment of collaterals is strongly associated with symptomatic bleeding after treatment with IV-rTPA.Disclosure: Dr. Yeo has nothing to disclose. Dr. Paliwal has nothing to disclose. Dr. Teoh has nothing to disclose. Dr. Seet has nothing to disclose. Dr. Ting has nothing to disclose. Dr. Chan has nothing to disclose. Dr. Rathakrishnan has nothing to disclose. Dr. Ong has nothing to disclose. Dr. Sharma has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Yeo, L., Paliwal, P., Teoh, H. L., Seet, C. S., Ting, E., Chan, B., Rathakrishnan, R., Ong, J., Sharma, V. Tags: Cerebrovascular Disease and Interventional Neurology: t-PA Source Type: research

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