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Age- and Weight-Adapted Dose of Prasugrel Versus Standard Dose of Ticagrelor in Patients With Acute Coronary Syndromes: Results From a Randomized Trial.
CONCLUSION: In elderly or low-weight patients with ACS, a reduced dose of prasugrel compared with the standard dose of ticagrelor is associated with maintained anti-ischemic efficacy while protecting these patients against the excess risk for bleeding. PRIMARY FUNDING SOURCE: German Center for Cardiovascular Research and Deutsches Herzzentrum München. PMID: 32687741 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 20, 2020 Category: Internal Medicine Authors: Menichelli M, Neumann FJ, Ndrepepa G, Mayer K, Wöhrle J, Bernlochner I, Richardt G, Witzenbichler B, Sibbing D, Gewalt S, Angiolillo DJ, Lahu S, Hamm CW, Hapfelmeier A, Trenk D, Laugwitz KL, Schunkert H, Schüpke S, Kastrati A Tags: Ann Intern Med Source Type: research

Non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation and atrial thrombosis: An appraisal of current evidence.
iety of Cardiology Abstract Major thromboembolic complications in patients with atrial fibrillation, secondary to thromboembolism from the left atrium or the left atrial appendage, are a major concern because of their burden of disabling stroke and mortality. To date, non-vitamin K antagonist oral anticoagulants (NOACs) are considered the first-line strategy in most patients with atrial fibrillation receiving chronic anticoagulation, as they have major advantages compared with vitamin K antagonists, including minimization of intracranial bleeding risk. Although several studies and post-hoc analyses have provided i...
Source: Archives of Cardiovascular Diseases - July 21, 2020 Category: Cardiology Authors: Calabrò P, Gragnano F, Cesaro A, Marsico F, Pariggiano I, Patti G, Moscarella E, Cavallari I, Sardu C, Parato VM, Renda G, Niccoli G, Marcucci R, De Caterina R, Working Group of Thrombosis and, Working Group of Interventional Cardiology of the Italian So Tags: Arch Cardiovasc Dis Source Type: research

Direct oral anticoagulants for patients aged over 80 years in nonvalvular atrial fibrillation: the impact of frailty
Conclusion Our study highlights how DOACs are a safe and effective option for anticoagulation, even in frail elderly people; the introduction of these drugs is leading to an increased use of anticoagulation therapy in this population. Prospective trials will be needed to reinforce these results and to consider new variables in the thrombotic and hemorrhagic risk scores underlying the prescription of DOACs.
Source: Journal of Cardiovascular Medicine - July 30, 2020 Category: Cardiology Tags: Research articles: Arrhythmias Source Type: research

Low-Dose Ticagrelor in Patients With High Ischemic Risk and Previous Myocardial Infarction: A Multicenter Prospective Real-World Observational Study
In conclusion, in a real-world study, including patients with previous MI, low-dose ticagrelor for prolonged dual antiplatelet therapy showed to be effective and safe, with no major bleeding occurring at follow-up.
Source: Journal of Cardiovascular Pharmacology - August 1, 2020 Category: Cardiology Tags: Original Article Source Type: research

Comparing the Safety and Effectiveness of Five Leading New-Generation Devices for Transcatheter Aortic Valve Implantation: Twelve-Month Results From the RISPEVA Study
CONCLUSION: Leading current-generation TAVI devices offer similarly favorable results at mid-term follow-up.PMID:33739300
Source: The Journal of Invasive Cardiology - March 19, 2021 Category: Cardiology Authors: Nicola Corcione Alberto Morello Paolo Ferraro Michele Cimmino Luca Testa Anna Sonia Petronio Alessandro Iadanza Antonio L Bartorelli Sergio Berti Damiano Regazzoli Enrico Romagnoli Carmen Spaccarotella Maurizio Tespili Martino Pepe Giacomo Frati Giuseppe Source Type: research

Patient Preferences of Low-Dose Aspirin for Cardiovascular Disease and Colorectal Cancer Prevention in Italy: A Latent Class Analysis
ConclusionPatient preferences for the benefits and risks of low-dose aspirin differ significantly among people eligible for treatment as primary or secondary CVD prevention.
Source: The Patient - Patient-Centered Outcomes Research - April 8, 2021 Category: International Medicine & Public Health Source Type: research

Implications of atrial fibrillation on the clinical course and outcomes of hospitalized COVID-19 patients: results of the Cardio-COVID-Italy multicentre study
ConclusionAmong hospitalized patients with COVID-19, a history of AF contributes to worse clinical course with a higher mortality and in-hospital events including new-onset AF, acute HF, and multiorgan failure. The mortality risk remains significant after adjustment for variables associated with COVID-19 severity and comorbidities.
Source: Europace - July 23, 2021 Category: Cardiology Source Type: research

Fibonacci ’ s Tree – Winner of Hysteria 2013
Fibonacci’s Tree by Tracy Fells ‘Here I am!’ I jab a finger, one of the few that still works, at the notebook page. ‘Right at the bottom of the tree.’ Tanya is adding too much milk to my tea. She doesn’t think I’m looking when she shoves a custard cream into her mouth. It disappears whole like an envelope propelled through a gaping letterbox. Crumbs splutter across the back of my useless left hand as she chants, ‘Teatime, Ellie. Sorry, we’re out of custard creams, but I’ve saved you a Bourbon. They’re your favourites.’ I can hear the words inside my head. They are crisp and clear like Mum’s be...
Source: The Hysterectomy Association - December 5, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Hysteria hysteria 2 hysteria 2013 hysteria winners short story Source Type: news

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