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Stroke and endocarditis: Reversing the point of view. A retrospective, cohort study
Endocarditis is a rare cause of cardioembolic ischemic or hemorrhagic stroke, leading to high mortality and morbidity.1
Source: Journal of Stroke and Cerebrovascular Diseases - January 17, 2023 Category: Neurology Authors: Irene Scala, Pier Andrea Rizzo, Paola Del Giacomo, Simone Bellavia, Giovanni Frisullo, Eleonora Rollo, Valerio Brunetti, Katleen De Gaetano Donati, Giacomo Della Marca Tags: Short Communication Source Type: research

Low NIHSS score large vessel occlusion caused by infective endocarditis treated with thrombectomy
A 24-year-old woman had undergone dental treatment 3 weeks before and had a mild fever for a week. She presented to the emergency department with the chief complaint of weakness in the right upper limb after waking up. She had mild paralysis of the right upper limb (National Institutes of Health Stroke Scale [NIHSS] score 1). Head magnetic resonance imaging (MRI) showed scattered infarcts in the left frontal and parietal lobes and left internal cerebral artery (ICA) occlusion (Fig. 1A, B). Cerebral angiography showed that the left ICA was occluded immediately after its origin (Fig.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2022 Category: Neurology Authors: So Matsukawa, Kohichi Go, Tao Yang, Takahisa Katsuki, Yohei Takenobu, Kenji Hashimoto Tags: Case Report Source Type: research

Neurological Complications and Clinical Outcomes of Infective Endocarditis
The aim of this study is to explore the clinical features associated with neurological complications of infective endocarditis (IE) and to assess the impact of neurological complications on clinical outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - July 4, 2022 Category: Neurology Authors: Alvin S. Das, Morgan McKeown, Stephanie A. Jordan, Karen Li, Robert W. Regenhardt, Steven K. Feske Source Type: research

Infectious Causes of Stroke
Stroke is one of the primary causes of mortality and morbidity worldwide. It can be ischemic or hemorrhagic, and the former can be due to an in-situ thrombus or a distant embolus. Despite being a rare cause, stroke can also be caused in the setting of infection. Bacterial agents are the most common cause of stroke, among other infectious agents. Until the antibiotic era, rheumatic heart disease was a predisposing risk factor of infective endocarditis. VZV is the most common cause of strokes in pediatric and adult populations.
Source: Journal of Stroke and Cerebrovascular Diseases - January 27, 2022 Category: Neurology Authors: Sireesha Murala, Elanagan Nagarajan, Pradeep C. Bollu Tags: Review Article Source Type: research

Endovascular Treatment of Infective Endocarditis-Related Acute Large Vessel Occlusion Stroke
Embolic stroke is a frequent complication of infective endocarditis yet lacks acute treatment as intravenous thrombolysis should be avoided due to high risk of intracerebral hemorrhage. Mechanical thrombectomy for large vessel occlusion may be a promising treatment but there is limited data on safety outcomes in infective endocarditis.
Source: Journal of Stroke and Cerebrovascular Diseases - April 8, 2021 Category: Neurology Authors: Elie Sader, Mohamad Abdalkader, Natalie Thom, Thanh N. Nguyen, Sandra McDonald, David Greer, Stacy C. Brown, Alaa Mohamedali, Jose Gutierrez, Hang Shi, Jane Morris, Victor Lopez-Rivera, Sunil A. Sheth, Kelly L. Sloane, Aneesh Singhal, Kunakorn Atchaneeyas Source Type: research

Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Unsuspected Infective Endocarditis
Infective endocarditis (IE) is considered to be an absolute contraindication for intravenous tissue plasminogen activator treatment (IVtPA) in acute ischemic stroke (AIS). However, during the hyperacute stroke evaluation, the exclusion of IE may be difficult. We sought to report the prevalence of undiagnosed IE in AIS patients who received IVtPA.
Source: Journal of Stroke and Cerebrovascular Diseases - December 23, 2020 Category: Neurology Authors: Mangala Gopal, Sushil Lakhani, Vivien H. Lee Tags: Case Report Source Type: research

Management of Large Vessel Occlusion Stroke Related to Infective Endocarditis: Is Mechanical Thrombectomy a Safe Option?
Acute ischemic stroke is the most common neurological complication of infective endocarditis. Intravenous thrombolysis is contraindicated in these patients due to a higher risk of hemorrhagic complications. Whether mechanical thrombectomy has some benefit in these patients remains unanswered although some favorable results can be found in literature.
Source: Journal of Stroke and Cerebrovascular Diseases - August 20, 2020 Category: Neurology Authors: Carmen Ramos, Pablo Mayo, Santiago Trillo, Carlos G ómez-Escalonilla, Jose Luis Caniego, Manuel Moreu, Juan Vega, Santiago Rosati, Patricia Simal, Álvaro Ximénez Carrillo, Jose Antonio Egido, José Vivancos Source Type: research

Diagnostic Performances of the Susceptibility Vessel Sign on MRI for the Prediction of Macroscopic Thrombi Features in Acute Ischemic Stroke
In 20% –40% of cases the etiology of acute ischemic stroke (AIS) remains uncertain despite complete diagnostic investigation.1 Correlations between the histological microscopic features of the thrombus and the TOAST (Trial of Org 10 172 in Acute Stroke Treatment) categories have been found.2–5 However, from the macroscopic point of view, only one case report has considered the chromatic visual aspect of the retrieved thrombus.6 Recently, the “white” visual aspect of the thrombus at the moment of withdrawal has been related to atypical etiologies, in particular infective endocarditis.
Source: Journal of Stroke and Cerebrovascular Diseases - August 20, 2020 Category: Neurology Authors: Romain Bourcier, Zo é Duchmann, Alessandro Sgreccia, Hubert Desal, Giuseppe Carità, Jean Philippe Desilles, Bertrand Lapergue, Arturo Consoli Source Type: research

Safety and Efficacy of Thrombolysis and Mechanical Thrombectomy in Infective Endocarditis
We read with much interest the article “Acute Ischemic Stroke Treatment in Infective Endocarditis: Systemic Review” by Bettencourt et al, published in your esteemed journal. Authors have reviewed 37 articles including 52 patients. Sixteen of whom received IV thrombolysis, 22 received mechanical thrombectomy, 11 received combined trea tment. The authors stated that the quality of the articles were low. And have concluded that the risk of intracerebral hemorrhage was 4 times higher in the group treated with IV thrombolysis comparing to the group treated with thrombectomy.
Source: Journal of Stroke and Cerebrovascular Diseases - March 20, 2020 Category: Neurology Authors: Ajay Kumar Mishra, Kamal Kant Sahu, Anu Anna George, Amos Lal Tags: Letter to the editor Source Type: research

Response to the Letter by Ajay K Mishra and Co-workers Commenting on “Safety and Efficacy of Thrombolysis and Mechanical Thrombectomy in Infective Endocarditis”
We thank you for your interest in our recent systematic review and share your view that the efficacy results of thrombolysis and mechanical thrombectomy in infective endocarditis should be read with caution, because of the low quality of available evidence, as shown in our review.
Source: Journal of Stroke and Cerebrovascular Diseases - March 19, 2020 Category: Neurology Authors: Sofia Bettencourt, Jos é M. Ferro Tags: Letter to the Editor Source Type: research

Acute Ischemic Stroke Treatment in Infective Endocarditis: Systematic Review
Background: Ischemic stroke is a frequent neurologic complication of infective endocarditis. This systematic review aims to evaluate the efficacy and safety of thrombectomy in comparison to thrombolysis and to combined treatment in patients with infective endocarditis associated acute ischemic stroke. Methods: A systematic literature review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The review included case reports, cases series, cross-sectional studies, case control studies, randomized controlled trials or nonrandomized controlled trials, which reported the treat...
Source: Journal of Stroke and Cerebrovascular Diseases - February 2, 2020 Category: Neurology Authors: Sofia Bettencourt, Jos é M Ferro Source Type: research

Mechanical Thrombectomy in Stroke from Infective Endocarditis: Case Report and Review
To characterize outcomes after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) from infective endocarditis.
Source: Journal of Stroke and Cerebrovascular Diseases - November 12, 2019 Category: Neurology Authors: Kelly L. Sloane, Scott B. Raymond, James D. Rabinov, Aneesh B. Singhal Source Type: research

The Spectrum of Nontraumatic Convexity Subarachnoid Hemorrhage
Background: Nontraumatic convexity subarachnoid hemorrhage (cSAH) is a nonaneurysmal variant that is associated with diverse etiologies. Methods: With IRB approval, we retrospectively reviewed consecutive nontraumatic cSAH from July 1, 2006 to July 1, 2016. Data were abstracted on demographics, medical history, neuroimaging, etiology, and clinical presentation. Results: We identified 94 cases of cSAH. The cases were classified according to the following etiologies: reversible cerebral vasoconstriction syndrome (RCVS) 17 (18%), cerebral amyloid angiopathy (CAA) 15 (16%), posterior reversible encephalopathy syndrome 16 (17%)...
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2019 Category: Neurology Authors: Rachel Forman, James J. Conners, Sarah Y. Song, Sayona John, Rajeev Garg, Jennifer Harris, Vivien H. Lee Source Type: research

Catastrophic Multiple Microbleeds Caused by Infective Endocarditis Following Intravenous Thrombolysis and Endovascular Thrombectomy
Ischemic stroke is one of the most common complications of infective endocarditis (IE). IE must be considered as one of the causes of acute ischemic stroke (AIS) with emergent large vessel occlusion (ELVO), but early diagnosis of IE is difficult. AIS with ELVO must be treated using endovascular thrombectomy (EVT), with or without intravenous thrombolysis (IVT). IVT for AIS due to IE is not well established and remains controversial because of the risk of intracranial hemorrhage. A 42-year-old man suffered from right hemiparesis and disorientation, and AIS with ELVO was diagnosed.
Source: Journal of Stroke and Cerebrovascular Diseases - June 19, 2019 Category: Neurology Authors: Ryosuke Maeoka, Ichiro Nakagawa, Hiroyuki Ohnishi, Kenkichi Takahashi, Hiroyuki Nakase, Hideyuki Ohnishi Tags: Case Report Source Type: research

Acute Ischemic Stroke Therapy in Infective Endocarditis: Case Series and Systematic Review
Objectives: To evaluate the safety of acute ischemic stroke (AIS) therapy in patients with infective endocarditis (IE) with intravenous thrombolysis (IVT) or endovascular therapy (EVT) such as mechanical thrombectomy. Methods: We conducted a retrospective study of patients who underwent AIS therapy with IVT or EVT at a tertiary referral center from 2013 to 2017, that were later diagnosed with acute IE as the causative mechanism. We then performed a systematic review of reports of acute ischemic reperfusion therapy in IE since 1995 for their success rates in terms of neurological outcome, and mortality, and their risk of he...
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2019 Category: Neurology Authors: Robert J. Marquardt, Sung-Min Cho, Prateek Thatikunta, Abhishek Deshpande, Dolora Wisco, Ken Uchino Source Type: research

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