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Heartbeat: knowledge gaps for non-bacterial thrombotic endocarditis
Non-bacterial thrombotic endocarditis (NBTE) contributes to adverse outcomes in patients with systemic inflammatory conditions, antiphospholipid syndrome or advanced malignancy (figure 1). Diagnosis is challenging and there is little data to guide prevention of adverse events, particularly stroke. In this issue of Heart, Quintero-Martinez and colleagues1 report the clinical characteristics and outcomes in 48 adults with NBTE identified at the Mayo Clinic over a 7 year period. Most patients (75%) were women with a mean age of 60 years and most cases were associated with malignancy (52%) or a systemic inflammatory disease (3...
Source: Heart - September 26, 2022 Category: Cardiology Authors: Otto, C. M. Tags: Highlights from this issue Source Type: research

230 Sydenhams chorea in an elderly patient
79 year old gentleman presented with multiple involuntary limb movements, initially referred to the acute medical unit as a seizure. After initial triage, he was managed as a dystonia. Patient was seen by ITU, and neurology opinion was requested. On consultant review, the ‘dancing type’ involuntary movements in limbs and in the face pointed towards a generalised chorea with mild athetosis of the left side, with expulsive speech. Patient also reported severe dental pain, and on examination, bloody ulcers and poor oral hygiene and dentition were noted. MRI showed acute small stroke of the left occipital area. Inf...
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Diyab, M., Bose, S., Awad, E., Zukos, I., Dasari, R. Tags: Poster Presentations Source Type: research

A Case Series Of Non-Bacterial Thrombotic Endocarditis Associated With Gynecological Malignancies (P6.248)
Conclusions:NBTE is an important ischemic stroke mechanism. We have reported three cases where the underlying malignancy was gynecological (endometrial, ovarian, and cervical). In the first two cases, the malignancy was discovered during the investigations for the stroke mechanism, while the third had a known underlying malignancy. This series highlights the need to consider gynecological malignancies as an underlying cause of stroke in young women; and that the ischemic event can occur prior to the malignancy diagnosis.Disclosure: Dr. Schabas has nothing to disclose. Dr.Teal has received personal compensation for activiti...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Schabas, A., Teal, P., Yip, S., Mann, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research