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Super High Dose Beta-blocker Administration for the Patients with Dilated Cardiomyopathy
First case is a 25-year-old female with dilated cardiomyopathy. Left ventricular end-diastolic diameter (LVEDD) was 74  mm and ejection fraction (EF) was 29%. Carvedilol was already uptitrated to 20 mg twice daily. Right heart catheterization (RHC) revealed very low cardiac output (C.O. 2.82 l/min), cardiac index (C.I. 1.47 l/min/m2), stroke volume (SV 29 ml) and rapid heart rate (HR 96/min) despite maximu m dosage of carvedilol in Japan. Carvedilol was uptitrated to 50 mg twice daily and additional 10 mg bisoprolol twice daily was started under administration of low-dose dobutamine.
Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Akihiro Isotani, Takashi Morinaga, Shintaro Mori, Shinya Ito, Makoto Hyodo, Shinichi Shirai, Kenji Ando Source Type: research

Patients Selection for Left Ventriculoplasty and Mitral Valve Surgery in Non-Ischemic Dilated Cardiomyopathy
The operative indication for dilated cardiomyopathy (DCM) is controversial. Subjects were 20 non-ischemic DCM patients. Left ventriculoplasty and mitral valve repair were conducted. Cardiac index derived from forward stroke volume significantly increased after surgery (from 1.8  ± 0.6 to 2.4 ± 0.6, P = .001). One-year survival rate was 58%. Slope in preload recruitable stroke work relationship (Mw) was an independent predictor for survival after surgery (HR, 0.936; 95%CI, 0.894–0.980; P = .005). Cut-off value of Mw for one-year survival was 42.
Source: Journal of Cardiac Failure - August 24, 2016 Category: Cardiology Authors: Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui Source Type: research

Stoke Work Index Predicts Left Ventricular Reverse Remodeling
To examine whether left ventricular stroke work index (LVSWI) predicts LV reverse remodeling after surgery for patients with ischemic dilated cardiomyopathy.
Source: Journal of Cardiac Failure - September 25, 2015 Category: Cardiology Authors: Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui Source Type: research