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Hydrogen sulfide in physiological and pathological mechanisms in brain.
Abstract Hydrogen sulfide (H2S) has been widely known as a toxic gas for more than 300 years in scientific community. However, the understanding about this small molecule has changed recently as many physiological and pathological roles of H2S have been identified. Presently, H2S is considered as a third gasotransmitter and neuromodulator after carbon monoxide (CO) and nitric oxide (NO). H2S plays an important role in memory and cognition through mechanisms that involve long-term potentiation (LTP) and calcium homeostasis in the neuronal cells. The disturbances in endogenous H2S levels and trans-sulfuration pathwa...
Source: CNS and Neurological Disorders Drug Targets - June 4, 2018 Category: Drugs & Pharmacology Authors: Kumar M, Sandhir R Tags: CNS Neurol Disord Drug Targets Source Type: research

Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome
Publication date: Available online 26 October 2015 Source:Trends in Pharmacological Sciences Author(s): Nader G. Abraham, Joshua M. Junge, George S. Drummond The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome. This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease. The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and cardiovascular disease (CVD). Recent reports indicate that HO-1/HO-2 prote...
Source: Trends in Pharmacological Sciences - October 27, 2015 Category: Drugs & Pharmacology Source Type: research