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Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: current evidence and potential use
CONCLUSION: This narrative review aims to update the existing literature on ALCAR molecular profile, tolerability, and translational clinical potential use in neurodegeneration, focusing on ALS.PMID:36998125 | DOI:10.2174/1871527322666230330083757
Source: CNS and Neurological Disorders Drug Targets - March 31, 2023 Category: Drugs & Pharmacology Authors: Fabiola De Marchi Sakthipriyan Venkatesan Massimo Saraceno Letizia Mazzini Elena Grossini Source Type: research

Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO
CNS Neurol Disord Drug Targets. 2023 Feb 3. doi: 10.2174/1871527322666230203140805. Online ahead of print.ABSTRACTThe gut microbiome interacts with the brain bidirectionally through the microbiome-gut-brain axis, which plays a key role in regulating various nervous system pathophysiological processes. Trimethylamine N-oxide (TMAO) is produced by choline metabolism through intestinal microorganisms, which can cross the blood-brain barrier to act on the central nervous system. Previous studies have shown that elevated plasma TMAO concentrations increase the risk of major adverse cardiovascular events, but there are few studi...
Source: CNS and Neurological Disorders Drug Targets - February 6, 2023 Category: Drugs & Pharmacology Authors: Ruxin Tu Jian Xia Source Type: research

A Comprehensive Review on Therapeutic Potential of Chrysin in Brain Related Disorders
This study depicts the relationship of chrysin with different brain related disorders and discusses the mechanisms responsible for the potential role of chrysin as a pharmacological agent for the treatment and management of different brain disorders, based on the results of several preclinical studies and taking into account the therapeutic effects of the compound.PMID:35657041 | DOI:10.2174/1871527321666220602111935
Source: CNS and Neurological Disorders Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Ahsas Goyal Geetanjali Singh Aanchal Verma Source Type: research

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