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Condition: Alzheimer's
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Total 1557 results found since Jan 2013.
Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news
Does self-directed learning address gaps in nursing student knowledge of Alzheimer's disease?
Educ Gerontol. 2023;49(8):673-686. doi: 10.1080/03601277.2022.2148445. Epub 2022 Dec 8.ABSTRACTIn the past two decades, deaths from stroke, heart disease and HIV decreased, whereas reported deaths from age-related Alzheimer's disease (AD) have increased. Future nurses will be caring for the rapidly escalating number of older adults facing increased AD risk, yet nursing students' knowledge has been shown to be limited regarding the age-related disease of Alzheimer's (and the most common dementia type) (Aljezawi et al., 2022; Mattos et al., 2015). In this pilot study, a quasi-experimental approach was used to examine undergr...
Source: Educational Gerontology - September 7, 2023 Category: Geriatrics Authors: Tamara Love Lisa Ann Kirk Wiese Vanessa Duncan Herlie Bertrand Source Type: research
Causal relationship between Alzheimer's disease and cardiovascular disease: a bidirectional Mendelian randomization analysis
This study applied a two-sample bidirectional Mendelian randomization method to explore the causal relationship between CVD and AD. Genome-wide association study (GWAS) data from 46 datasets of European populations (21,982 cases of AD and 41,944 controls) were utilized to obtain genetic instrumental variables for AD. In addition, genetic instrumental variables for atrial fibrillation (AF), heart failure (HF), myocardial infarction (MI), coronary heart disease (CHD), angina pectoris (AP), and ischemic stroke (IS) (including large-artery atherosclerotic stroke [LAS] and cardioembolic stroke [CES]) were selected from GWAS dat...
Source: Aging - September 4, 2023 Category: Biomedical Science Authors: Fengjun Zhang Dexian Xian Junchen Feng Luning Ning Tianshou Jiang Wenchang Xu Yuan Liu Qiong Zhao Min Peng Source Type: research
