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Neuroprotective effects of Senkyunolide I against glutamate-induced cells death by attenuating JNK/caspase-3 activation and apoptosis
Biomed Pharmacother. 2021 May 24;140:111696. doi: 10.1016/j.biopha.2021.111696. Online ahead of print.ABSTRACTGlutamate-induced neurotoxicity is one of the most important pathogenic mechanisms in neurological diseases and is widely used as an in vitro model for ischemic stroke. Senkyunolide I (SEI), an active constituent derived from traditional Chinese medicine Ligusticum chuanxiong Hort. and Angelica sinensis (Oliv.) Diels, has been shown to have beneficial effects against focal cerebral ischemia-reperfusion in rats. However, the mechanisms underlying SEI-mediated neuroprotection remain not well understood. Thus, we expl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2021 Category: Drugs & Pharmacology Authors: Min Wang Hideki Hayashi Ichiro Horinokita Mayumi Asada Yui Iwatani Jian-Xun Liu Norio Takagi Source Type: research