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Source: Toxicology
Cancer: Neuroblastoma
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Total 3 results found since Jan 2013.
Silibinin exerts neuroprotective effects against cerebral hypoxia/reoxygenation injury by activating the GAS6/Axl pathway
This study aimed to investigate the protective effects of SIL against cerebral ischemia-reperfusion injury in neuroblastoma N2a cells, and the mechanisms involved. Firstly, the toxicity of SIL was evaluated, and safe concentrations were chosen for subsequent experiments. Then, SIL exerts significant neuroprotection against hypoxia/reoxygenation (HR) injury in N2a cells, as manifested by increased cell viability, decreased apoptotic rate, LDH, and ROS generation. Additionally, SIL was found to inhibit HR-induced apoptosis, mitochondria dysfunction, and oxidative stress. However, silencing of GAS6 inhibited the neuroprotecti...
Source: Toxicology - August 6, 2023 Category: Toxicology Authors: Weiping Li Zhe Zhang Jiawen Li Jun Mu Meng Sun Xue Wu Xiaochen Niu Yang Yang Huanle Yan Xiaoling Xu Chengxu Xue Lu Qian Ye Tian Source Type: research
