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Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF- κB pathway by targeting FOXO3.
Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-κB pathway by targeting FOXO3. Exp Cell Res. 2018 Apr 28;: Authors: Guo D, Ma J, Li T, Yan L Abstract Dysfunction of the microRNA (miR) network has been emerging as a main regulator in ischemic stroke. Recently, studies have linked the deregulation of miR-122 to ischemic stroke. However, the specific role and molecular mechanism of miR-122 in ischemic stroke remain to be further investigated. Here, we found that miR-122 was decreased in mouse N2A neuroblastoma (N2A) cells af...
Source: Experimental Cell Research - April 28, 2018 Category: Cytology Authors: Guo D, Ma J, Li T, Yan L Tags: Exp Cell Res Source Type: research

Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Abstract 12/15-lipoxygenase (12/15-LOX) is involved in organelle homeostasis by degrading mitochondria in maturing red blood cells and by eliminating excess peroxisomes in liver. Furthermore, 12/15-LOX contributes to diseases by exacerbating oxidative stress-related injury, notably in stroke. Nonetheless, it is unclear what the consequences are of abolishing 12/15-LOX activity. Mice in which the alox15 gene has been ablated do not show an obvious phenotype, and LOX enzyme inhibition is not overtly detrimental. We show here that liver histology is also unremarkable. However, electron microscopy demonstrated that 12...
Source: Experimental Cell Research - November 26, 2013 Category: Cytology Authors: Jang I, Park S, Won Cho J, Yigitkanli K, van Leyen K, Roth J Tags: Exp Cell Res Source Type: research