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Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms
Publication date: June–August 2018Source: Progress in Neurobiology, Volumes 165–167Author(s): Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S. Kindy, Ayad A. Jaffa, Firas KobeissyAbstractNeurological disorders represent major health concerns in terms of comorbidity and mortality worldwide. Despite a tremendous increase in our understanding of the pathophysiological processes involved in disease progression and prevention, the accumulated knowledge so far resulted in relatively moderate translational benefits in terms of therapeutic interventions and enhanced clinical outcomes. Aiming at spe...
Source: Progress in Neurobiology - July 10, 2018 Category: Neuroscience Source Type: research

Implication of the Kallikrein-Kinin System on Neurological Disorders: Quest for Potential Biomarkers and Mechanisms
Publication date: Available online 31 January 2018 Source:Progress in Neurobiology Author(s): Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S. Kindy, Ayad A. Jaffa, Firas Kobeissy Neurological disorders represent major health concerns in terms of comorbidity and mortality worldwide. Despite a tremendous increase in our understanding of the pathophysiological processes involved in disease progression and prevention, the accumulated knowledge so far resulted in relatively moderate translational benefits in terms of therapeutic interventions and enhanced clinical outcomes. Aiming at specific neur...
Source: Progress in Neurobiology - March 2, 2018 Category: Neuroscience Source Type: research

Translational potential of astrocytes in brain disorders
Publication date: Available online 16 September 2015 Source:Progress in Neurobiology Author(s): Alexei Verkhratsky, Luca Steardo, Vladimir Parpura, Vedrana Montana Fundamentally, all brain disorders can be broadly defined as the homeostatic failure of this organ. As the brain is composed of many different cells types, including but not limited to neurons and glia, it is only logical that all the cell types/constituents could play a role in health and disease. Yet, for a long time the sole conceptualization of brain pathology was focused on the well-being of neurons. Here, we challenge this neuron-centric view and pre...
Source: Progress in Neurobiology - September 17, 2015 Category: Neuroscience Source Type: research