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Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway
Am J Chin Med. 2022 Jul 29:1-33. doi: 10.1142/S0192415X22500665. Online ahead of print.ABSTRACTCurrently, therapies for ischemic stroke are limited. Ginkgolides, unique Folium Ginkgo components, have potential benefits for ischemic stroke patients, but there is little evidence that ginkgolides improve neurological function in these patients. Clinical studies have confirmed the neurological improvement efficacy of diterpene ginkgolides meglumine injection (DGMI), an extract of Ginkgo biloba containing ginkgolides A (GA), B (GB), and K (GK), in ischemic stroke patients. In the present study, we performed transcriptome analys...
Source: The American Journal of Chinese Medicine - July 28, 2022 Category: Complementary Medicine Authors: Tuan-Jie Wang Zi-Yin Wu Chun-Hua Yang Liang Cao Zhen-Zhong Wang Ze-Yu Cao Ming-Yang Yu Meng-Ru Zhao Chen-Feng Zhang Wen-Jun Liu Bin-Jiang Zhao Xue-Qi Shang Yu Feng Hui Wang Li-Li Deng Bao-Guo Xiao Hong-Yan Guo Wei Xiao Source Type: research