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Cardiovascular Complications of Targeted Therapies for Chronic Myeloid Leukemia
Opinion statementThe development of tyrosine kinase inhibitors (TKIs) dramatically changed the treatment landscape for many different cancers including chronic myeloid leukemia (CML). With the introduction of imatinib, the first TKI developed and approved to effectively treat CML, patient survival has increased dramatically and, in some cases, this fatal cancer can be managed as a chronic disease. Since the approval of imatinib in 2002, four additional TKIs have been developed to treat this disease including the second-generation TKIs nilotinib, dasatinib, and bosutinib and the third-generation TKI ponatinib. Despite their...
Source: Current Treatment Options in Cardiovascular Medicine - March 17, 2017 Category: Cardiology Source Type: research