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Design, synthesis, and negative inotropic evaluation of 4 ‐phenyl‐1H‐1,2,4‐triazol‐5(4H)‐one derivatives containing triazole or piperazine moieties
This article is protected by copyright. All rights reserved. Four novel series of 4‐phenyl‐1H‐1,2,4‐triazol‐5(4H)‐one derivatives containing triazole or piperazine moieties were designed, synthesized, and evaluated for negative inotropic activity. The cytotoxicity of these compounds was evaluated and a preliminary investigation of the mechanism of action of these compounds on the atrial dynamics was also conducted.
Source: Chemical Biology and Drug Design - July 28, 2016 Category: Biology Authors: Zhi ‐Yu Wei, Bai‐Ri Cui, Xun Cui, Yan‐Ling Wu, Yang Fu, Li‐Ping Liu, Hu‐Ri Piao Tags: Research Article Source Type: research

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Biology Authors: Ali Hochberg Source Type: news