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Source: Pharmacological Research
Cancer: Gastrointestinal Stromal Tumor (GIST)
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Expanding spectrum of anticancer drug, imatinib, in the disorders affecting brain and spinal cord
Publication date: Available online 19 March 2019Source: Pharmacological ResearchAuthor(s): Manish Kumar, Ritu Kulshrestha, Nirmal Singh, Amteshwar Singh JaggiAbstractImatinib is a tyrosine kinase inhibitor and is used as a first line drug in the treatment of Philadelphia-chromosome-positive chronic myeloid leukaemia and gastrointestinal stromal tumors. Being tyrosine kinase inhibitor, imatinib modulates the activities of Abelson gene (c-Abl), Abelson related gene (ARG), platelet-derived growth factor receptor (PDGFR), FMS-like tyrosine kinase 3 (FLT3), lymphocyte-specific protein (Lck), mitogen activated protein kinase (MA...
Source: Pharmacological Research - March 20, 2019 Category: Drugs & Pharmacology Source Type: research
