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Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy.
Abstract 12/15-lipoxygenase (12/15-LOX) is involved in organelle homeostasis by degrading mitochondria in maturing red blood cells and by eliminating excess peroxisomes in liver. Furthermore, 12/15-LOX contributes to diseases by exacerbating oxidative stress-related injury, notably in stroke. Nonetheless, it is unclear what the consequences are of abolishing 12/15-LOX activity. Mice in which the alox15 gene has been ablated do not show an obvious phenotype, and LOX enzyme inhibition is not overtly detrimental. We show here that liver histology is also unremarkable. However, electron microscopy demonstrated that 12...
Source: Experimental Cell Research - November 26, 2013 Category: Cytology Authors: Jang I, Park S, Won Cho J, Yigitkanli K, van Leyen K, Roth J Tags: Exp Cell Res Source Type: research

Diabetes is not an independent risk factor for hepatocellular carcinoma
ConclusionsDiabetes is not an independent risk factor for HCC after considering the effects of alcohol‐related diagnoses, chronic liver disease and potential detection bias. This article is protected by copyright. All rights reserved.
Source: Diabetes/Metabolism Research and Reviews - May 1, 2013 Category: Endocrinology Authors: Chin‐Hsiao Tseng Tags: Research Article Source Type: research

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