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Acute Isolated Paraplegia Revealing an Ewing Sarcoma of the Thoracic Spine
In this report, we present the case of a child with ES localized at the upper thoracic level. ES was revealed by isolated acute complete paraplegia mimicking medullary stroke. The girl was operated for decompressive laminectomy and tumor removal. Afterwards, she received adjuvant therapy. Subsequently, the child showed a slow improvement of her leg sensitivity associated with a partial motor recovery. ES can affect the mobile spine. Acute symptomatology due to intratumoral hemorrhage and sudden spinal cord compression may suggest the diagnosis. Neurological outcomes following ES are generally poor.
Source: Journal of Pediatric Hematology Oncology - October 26, 2017 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Targeting the EWS–FLI1 transcription factor in Ewing sarcoma
Conclusions The encouraging clinical benefit observed with the combination and its good tolerability deserves further investigation in Ewing sarcoma.
Source: Cancer Chemotherapy and Pharmacology - May 23, 2015 Category: Cancer & Oncology Source Type: research