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Modulation of A-type K(+) channels by the short-chain cobrotoxin through the protein kinase C-delta isoform decreases membrane excitability in dorsal root ganglion neurons.
In this study, we identified the functional role of cobrotoxin, the short-chain α-neurotoxin isolated from Naja atra venom, which acts in the regulation of the transient A-type K(+) currents (I(A)) and membrane excitability in dorsal root ganglion (DRG) neurons via the activation of the muscarinic M3 receptor (M3R). Our results showed that cobrotoxin increased I(A) in a concentration-dependent manner, whereas the sustained delayed rectifier K(+) currents (I(DR)) were not affected. Cobrotoxin did not affect the activation of I(A) markedly, however, it shifted the inactivation curve significantly in the depolarizing directi...
Source: Biochemical Pharmacology - February 19, 2013 Category: Drugs & Pharmacology Authors: Guo Q, Jiang YJ, Jin H, Jiang XH, Gu B, Zhang YM, Wang JG, Qin ZH, Tao J Tags: Biochem Pharmacol Source Type: research
