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Targeting the honey bee gut parasite Nosema ceranae with siRNA positively affects gut bacteria
Gut microbial communities can contribute positively and negatively to host health. So far, eight core bacterial taxonomic clusters have been reported in honey bees. These bacteria are involved in host metaboli...
Source: BMC Microbiology - August 17, 2020 Category: Microbiology Authors: Qiang Huang and Jay D. Evans Tags: Research article Source Type: research

Caspase-3-independent apoptotic pathways contribute to interleukin-32¿-mediated control of Mycobacterium tuberculosis infection in THP-1 cells
Conclusions: The anti-MTB effects of IL-32γ are mediated through classical caspase-3-dependent apoptosis as well as caspase-3-independent apoptosis.
Source: BMC Microbiology - February 21, 2015 Category: Microbiology Authors: Xiyuan BaiWilliam KinneyWen-Lin SuAn BaiAlida OvrutskyJennifer HondaMihai NeteaMarcela Henao-TamayoDiane OrdwayCharles DinarelloEdward Chan Source Type: research

Chlamydia pneumoniae effector chlamydial outer protein N sequesters fructose bisphosphate aldolase A, providing a benefit to bacterial growth
Conclusions: We discovered that one of the C. pneumoniae CopN targets is the glycolytic enzyme aldolase A. Sequestering aldolase A may be beneficial to bacterial growth in infected host cells.
Source: BMC Microbiology - December 21, 2014 Category: Microbiology Authors: Kasumi IshidaJunji MatsuoYoshimasa YamamotoHiroyuki Yamaguchi Source Type: research

Bacillus anthracis genomic DNA enhances lethal toxin¿induced cytotoxicity through TNF-¿ production
Conclusions: Our results suggest that B. anthracis DNA may contribute to anthrax pathogenesis by enhancing LT activity via TLR9-mediated TNF-? production.
Source: BMC Microbiology - December 4, 2014 Category: Microbiology Authors: Jun JeonYeon KimMin ChoiKyung KimHae-Ri LeeJeyoun JangYu-Ri KimJeong-Hoon ChunSeong EoTae KimGi-eun Rhie Source Type: research

Differential regulation of interleukin-8 and human beta-defensin 2 in Pseudomonas aeruginosa -infected intestinal epithelial cells
Conclusions: The P. aeruginosa-induced antimicrobial peptide in IECs continuously protect the host against prolonged infection, while modulation of proinflammatory responses prevents the host from the detrimental effects of overwhelming inflammation. Thus, P. aeruginosa-induced innate immunity in IECs represents a host protective mechanism, which may provide new insight into the pathogenesis of inflammatory bowel diseases.
Source: BMC Microbiology - November 30, 2014 Category: Microbiology Authors: Fu-Chen Huang Source Type: research

Gene silencing of beta-galactosamide alpha-2,6-sialyltransferase 1 inhibits human influenza virus infection of airway epithelial cells
Conclusions: We used siRNAs targeting ST6GAL1 to inhibit the expression of certain cell surface receptors, thereby preventing virus adsorption. This resulted in the inhibition of human influenza virus infection. Our findings are a significant development in the identification of potential new anti-influenza drug targets.
Source: BMC Microbiology - Latest articles - March 27, 2014 Category: Microbiology Authors: Dong WuWenbo HuangYutao WangWenda GuanRunfeng LiZifeng YangNanshan Zhong Source Type: research

Gene silencing of ß-galactosamide ¿-2,6-sialyltransferase 1 inhibits human influenza virus infection of airway epithelial cells
Conclusions: We used siRNAs targeting ST6GAL1 to inhibit the expression of certain cell surface receptors, thereby preventing virus adsorption. This resulted in the inhibition of human influenza virus infection. Our findings are a significant development in the identification of potential new anti-influenza drug targets.
Source: BMC Microbiology - Latest articles - March 27, 2014 Category: Microbiology Authors: Dong WuWenbo HuangYutao WangWenda GuanRunfeng LiZifeng YangNanshan Zhong Source Type: research

Inhibition of HSP70 reduces porcine reproductive and respiratory syndrome virus replication in vitro
Conclusions: Our study revealed that HSP70 is an essential host factor required for the replication of PRRSV. The inhibition of HSP70 significantly reduced PRRSV replication, which may be applied as an effective antiviral strategy.
Source: BMC Microbiology - Latest articles - March 13, 2014 Category: Microbiology Authors: Jintao GaoShuqi XiaoXiaohong LiuLiangliang WangQianqian JiDelin MoYaosheng Chen Source Type: research

Lipopolysaccharide (LPS)-induced autophagy is involved in the restriction of Escherichia coli in peritoneal mesothelial cells
Conclusions: Our findings demonstrated for the first time that LPS-induced autophagy in peritoneal mesothelial cells could enhance the intracellular bactericidal activity and the co-localization of E.coli with autophagosomes. The activation of TLR4 signaling was involved in this process. These results indicate that LPS-induced autophagy may be a cell-autonomous defense mechanism triggered in peritoneal mesothelial cells in response to E.coli infection.
Source: BMC Microbiology - Latest articles - November 13, 2013 Category: Microbiology Authors: Juan WangXiaoran FengYoujia ZengJinjin FanJuan WuZhijian LiXinhui LiuRong HuangFengxian HuangXueqing YuXiao Yang Source Type: research

Identification of conserved motifs in the Westnile virus envelope essential for particle secretion
Conclusions: The conserved 461PXAP464 and 349YCYL352 motifs in the WNV envelope are indispensable for WNV particle production. Although these motifs bear sequence similarity to retroviral late domains and are essential for WNV assembly, they are functionally distinct suggesting that they are not the typical late domain like motifs of retroviruses and may play a role other than Alix/Tsg101 utilization/dependence.
Source: BMC Microbiology - Latest articles - September 4, 2013 Category: Microbiology Authors: Himanshu GargRaphael LeeNg TekSebastian Maurer-StrohAnjali Joshi Source Type: research

Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells
Conclusions: The accumulation of the RhoA and Rac1 on the PVM and the requisite of their normal GTPase activity for efficient invasion implied their involvement and function in T. gondii invasion.
Source: BMC Microbiology - Latest articles - May 30, 2013 Category: Microbiology Authors: Ren-Hua NaGuo-Hui ZhuJi-Xuan LuoXiao-Jing MengLiwang CuiHong-Juan PengXiao-guang ChenJulian Gomez-Cambronero Source Type: research