Filtered By:
Specialty: Physics
Cancer: Pancreatic Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 11 results found since Jan 2013.
Thymidine phosphorylase induction by ionizing radiation antagonizes 5-fluorouracil resistance in human ductal pancreatic adenocarcinoma
Radiat Environ Biophys. 2022 Jan 27. doi: 10.1007/s00411-022-00962-w. Online ahead of print.ABSTRACTChemoresistance in pancreatic ductal adenocarcinoma (PDAC) frequently contributes to failure of systemic therapy. While the radiosensitizing properties of 5-fluorouracil (FU) are well known, it is unknown whether ionizing radiation (IR) sensitizes towards FU cytotoxicity. Here, we hypothesize that upregulation of thymidine phosphorylase (TP) by IR reverses FU chemoresistance in PDAC cells. The FU resistant variant of the human PDAC cell line AsPC-1 (FU-R) was used to determine the sensitizing effects of IR. Proliferation rat...
Source: Radiation and Environmental Biophysics - January 27, 2022 Category: Physics Authors: Lucas D Lee Ioannis Pozios Verena Liu Silke B Nachbichler Dirk B öhmer Carsten Kamphues Katharina Beyer Christiane J Bruns Martin E Kreis Hendrik Seeliger Source Type: research
