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DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1
Conclusion DNA-PK directly phosphorylates NOR-1 and, this way, modulates SMC proliferation. These data add to our understanding of vascular remodelling processes and opens new avenues for treatment of vascular proliferative diseases.
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Medunjanin, S., Daniel, J.-M., Weinert, S., Dutzmann, J., Burgbacher, F., Brecht, S., Bruemmer, D., Kahne, T., Naumann, M., Sedding, D. G., Zuschratter, W., Braun-Dullaeus, R. C. Tags: Vascular biology Source Type: research

Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation
Conclusion Our findings demonstrate for the first time that inflammation disrupts LDLr feedback regulation through the activation of the mTOR pathway. Increased mTORC1 activity was found to up-regulate SREBP-2-mediated cholesterol uptake through Rb phosphorylation.
Source: Cardiovascular Research - November 13, 2013 Category: Cardiology Authors: Ma, K. L., Liu, J., Wang, C. X., Ni, J., Zhang, Y., Wu, Y., Lv, L. L., Ruan, X. Z., Liu, B. C. Tags: Vascular biology Source Type: research