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Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor α dependent pathway.
Abstract Restenosis is an adverse outcome of angioplasty, characterized by vascular smooth muscle cell (VSMC) hyperplasia. However, therapies targeting VSMC proliferation delay re-endothelialization, increasing the risk of thrombosis. Resveratrol (RESV) inhibits restenosis and promotes re-endothelialization after arterial injury, but in vitro studies assessing RESV-mediated effects on endothelial cell growth contradict these findings. We thus hypothesized that fluid shear stress, mimicking physiological blood flow, would recapitulate RESV-dependent endothelial cell wound healing. Since RESV is an estrogen receptor...
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 24, 2014 Category: Physiology Authors: Yurdagul A, Kleinedler J, McInnis MC, Khandelwal AR, Spence A, Orr AW, Dugas TR Tags: Am J Physiol Heart Circ Physiol Source Type: research