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Vasonatrin peptide attenuates myocardial ischemia/reperfusion injury in diabetic rats and underlying mechanisms.
Conclusions: VNP protects diabetic heart against ischemia/reperfusion injury by inhibiting ER stress via cGMP-PKG signaling pathway. These results suggest that VNP may have potential therapeutic value for the diabetic patients with ischemic heart disease. PMID: 25485902 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 5, 2014 Category: Physiology Authors: Shi Z, Fu F, Yu L, Xing W, Ji L, Tie R, Liang X, Zhu M, Yu J, Zhang H Tags: Am J Physiol Heart Circ Physiol Source Type: research