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Helicobacter pylori-induced post-transcriptional regulation of H,K-ATPase α subunit gene expression by miRNA.
Abstract Acute H. pylori infection of gastric epithelial cells induces CagA oncoprotein- and peptidoglycan (SLT)-dependent mobilization of NF-κB p50 homodimers that bind to H,K-ATPase α subunit (HKα) promoter and repress HKα gene transcription. This process may facilitate gastric H. pylori colonization by induction of transient hypochlorhydria. We hypothesized that H. pylori also regulates HKα expression post-transcriptionally by miRNA interaction with HKα mRNA. In silico analysis of HKα 3' untranslated region (UTR) identified miR-1289 as a highly-conserved putative HKα-regulatory miRNA. H. pylori infectio...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - February 6, 2014 Category: Physiology Authors: Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Smolka AJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research