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Smooth muscle cell FTO regulates contractile function
Am J Physiol Heart Circ Physiol. 2022 Oct 28. doi: 10.1152/ajpheart.00427.2022. Online ahead of print.ABSTRACTThe Fat mass and obesity gene (FTO) is a N6-methyladenosine RNA demethylase that was initially linked by GWAS studies to increased rates of obesity. Subsequent studies have revealed multiple mass-independent effects of the gene, including cardiac myocyte contractility. We created a mouse with a conditional and inducible smooth muscle cell deletion of Fto (Myh11 Cre + Ftofl/fl) and did not observe any changes in mouse body mass or mitochondrial metabolism. However, the mice had significantly decreased blood pressure...
Source: American Journal of Physiology. Heart and Circulatory Physiology - October 28, 2022 Category: Physiology Authors: Melissa A Luse Nenja Kr üger Miranda E Good Lauren A Biwer Vlad Serbulea Anita Salamon Rebecca A Deaton Norbert Leitinger Axel G ödecke Brant E Isakson Source Type: research

Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension
Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00220.2022. Online ahead of print.ABSTRACTMechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically-activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 23, 2022 Category: Physiology Authors: Siyu Tian Zongye Cai Payel Sen Denise van Uden Esther van de Kamp Raphael Thuillet Ly Tu Christophe Guignabert Karin Boomars Kim Van der Heiden Maarten M Brandt Daphne Merkus Source Type: research

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