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A fast lasso-based method for inferring higher-order interactions
by Kieran Elmes, Astra Heywood, Zhiyi Huang, Alex Gavryushkin Large-scale genotype-phenotype screens provide a wealth of data for identifying molecular alterations associated with a phenotype. Epistatic effects play an important role in such association studies. For example, siRNA perturbation screens can be used to identify combinatorial gene-silencing effects. In bacteria, epistasis has practical consequences in determining antimicrobial resistance as the genetic background of a strain plays an important role in determining resistance. Recently developed tools scale to human exome-wide screens for pairwise interactions,...
Source: PLoS Computational Biology - December 29, 2022 Category: Biology Authors: Kieran Elmes Source Type: research