Filtered By:
Specialty: Chemistry
Infectious Disease: SARS
This page shows you your search results in order of date.
Order by Relevance | Date
Total 3 results found since Jan 2013.
Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs
Angew Chem Int Ed Engl. 2022 Jul 8. doi: 10.1002/anie.202204556. Online ahead of print.ABSTRACTTThe emergence of more transmissible or aggressive variants of SARS-CoV-2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis of chemically stabilized small interfering RNA (siRNA) against SARS-CoV-2. The siRNA can be further modified with receptor ligands such as peptides using Cu(I)-catalysed click-chemistry. We demonstrate that optimized siRNAs can reduce viral loads and virus-induced cytotoxicity by up to five orders of magnitude in cell ...
Source: Angewandte Chemie - July 8, 2022 Category: Chemistry Authors: Franziska R Traube Marcel Stern Annika J T ölke Martina Rudelius Ernesto Mej ías-Pérez Nada Raddaoui Beate M K ümmerer C éline Douat Filipp Streshnev Manuel Albanese Paul R Wratil Yasmin V G ärtner Milda Nainyt ė Grazia Giorgio Stylianos Michalakis Source Type: research
