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Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblasts
We assessed the response of primary cultures of placental villous mononucleated trophoblasts and multinucleated syncytiotrophoblast to calcitriol, the most biologically active form of vitamin D. Whole-genome microarray data showed that calcitriol modulates the expression of many genes in trophoblasts within 6 hours of exposure and RT-qPCR revealed similar responses in cytotrophoblasts, syncytiotrophoblasts and villous explants. Both cytotrophoblasts and syncytiotrophoblasts expressed genes for the vitamin D receptor, for LRP2 and CUBN that mediate internalization of calcidiol, for CYP27B1 that encodes the enzyme that conve...
Source: Reproduction - October 31, 2017 Category: Reproduction Medicine Authors: Longtine, M. S., Cvitic, S., Colvin, B. N., Chen, B., Desoye, G., Nelson, D. M. Tags: Research Source Type: research