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Vaccination: Cancer Vaccines
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Mismatch in epitope specificities between IFNγ inflamed and uninflamed conditions leads to escape from T lymphocyte killing in melanoma
Conclusions:
Our results illustrate a little-studied mechanism of immune escape by tumor cells which, with appropriate understanding and treatment, may be reversible. These data have implications for the design of cancer vaccines and adoptive T cell therapies.
Source: Epidemiologic Perspectives and Innovations - February 16, 2016 Category: Epidemiology Authors: Katherine WoodsAshley J. KnightsMatthew AnakaRalf SchittenhelmAnthony PurcellAndreas BehrenJonathan Cebon Source Type: research