• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression
ConclusionsSignal transducer and activator of transcription 5 plays an important role in hepatic fat metabolism through regulation of CD36, and is a potential therapeutic candidate for liver steatosis.
Source: Hepatology Research - October 17, 2016 Category: Internal Medicine Authors: Atsushi Hosui, Tomohide Tatsumi, Hayato Hikita, Yoshinobu Saito, Naoki Hiramatsu, Masahiko Tsujii, Lothar Hennighausen, Tetsuo Takehara Tags: Original Article Source Type: research

STAT5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression
CONCLUSIONS: STAT5 plays an important role in hepatic fat metabolism through regulation of CD36, and is a potential therapeutic candidate for liver steatosis.
Source: Hepatology Research - August 31, 2016 Category: Internal Medicine Authors: Atsushi Hosui, Tomohide Tatsumi, Hayato Hikita, Yoshinobu Saito, Naoki Hiramatsu, Masahiko Tsujii, Lothar Hennighausen, Tetsuo Takehara Tags: Original Article Source Type: research

Protecting liver sinusoidal endothelial cells suppresses apoptosis in acute liver damage
ConclusionHepatocyte apoptosis was reduced by the efficient suppression of LSEC apoptosis with a novel DDS. Protecting the sinusoidal structure by suppressing LSEC damage will be an effective treatment for acute liver failure. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - October 22, 2015 Category: Internal Medicine Authors: Tomohito Tanoi, Takafumi Tamura, Naoki Sano, Ken Nakayama, Kiyoshi Fukunaga, Yun‐Wen Zheng, Afsana Akhter, Yu. Sakurai, Yasuhiro Hayashi, Hideyoshi Harashima, Nobuhiro Ohkohchi Tags: Original Article Source Type: research

Glucagon‐like peptide‐1 preserves non‐alcoholic fatty liver disease through inhibition of the endoplasmic reticulum stress‐associated pathway
ConclusionGLP‐1 protected against NAFLD by inactivating the ER stress‐associated apoptosis pathway. In addition, the effect was possibly related to the signaling pathway of ERp46.
Source: Hepatology Research - August 18, 2015 Category: Internal Medicine Authors: Na Ao, Jing Yang, Xiaochen Wang, Jian Du Tags: Original Article Source Type: research

Glucagon‐like peptide‐1 (GLP‐1) preserves non‐alcoholic fatty liver disease (NAFLD) through inhibition of the endoplasmic reticulum (ER) stress‐associated pathway
ConclusionGLP‐1 protected against non‐alcoholic fatty liver disease by inactivating the ER stress‐associated apoptosis pathway. In addition, the effect was possibly related to the signaling pathway of ERp46. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - July 4, 2015 Category: Internal Medicine Authors: Na. Ao, Jing Yang, Xiaochen Wang, Jian Du Tags: Original Article Source Type: research

MiR‐486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON
ConclusionsOur data indicated that miR‐486 may function as a novel tumor suppressor in HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - February 5, 2015 Category: Internal Medicine Authors: Huiyan Sun, Chunping Cui, Fengjun Xiao, Hua Wang, Jun Xu, Xuefeng Shi, Yuefeng Yang, Qunwei Zhang, Xiaofei Zheng, Xiaoming Yang, Chutse Wu, Lisheng Wang Tags: Original Article Source Type: research

Role of transcription factor CCAAT/enhancer‐binding protein alpha in human fetal liver cell types in vitro
ConclusionWe demonstrated that the effects of C/EBPα are specific for the different human fetal liver cell types, using an advanced 3‐D perfusion bioreactor as a human in vivo‐like model.
Source: Hepatology Research - October 9, 2014 Category: Internal Medicine Authors: Jörg C. Gerlach, Patrick Over, Hubert G. Foka, Morris E. Turner, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer Tags: Original Article Source Type: research

Role ofTranscription Factor CCAAT/Enhancer Binding Protein Alphain Human Fetal LiverCell Typesin vitro
ConclusionsWe demonstrated that the effects of C/EBPα are specific for the different human fetal liver cell types, using an advanced three‐dimensional perfusion bioreactor as a humanin vivo‐like model.
Source: Hepatology Research - September 5, 2014 Category: Internal Medicine Authors: Jörg C. Gerlach, Patrick Over, Hubert G. Foka, Morris E. Turner, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer Tags: Original Article Source Type: research

Livin is associated with the invasive and oncogenic phenotypes of human hepatocellular carcinoma cells
ConclusionThese results suggest that Livin is associated with invasive and oncogenic phenotypes of human HCC cells.
Source: Hepatology Research - July 22, 2014 Category: Internal Medicine Authors: Sung‐Bum Cho, Wan‐Sik Lee, Young‐Lan Park, Nuri Kim, Hyung‐Hoon Oh, Mi‐Young Kim, Chan‐Young Oak, Cho‐Yun Chung, Hyung‐Chul Park, Jong‐Sun Kim, Dae‐Seong Myung, Sang‐Hoon Kim, Kyung‐Hwa Lee, Sung‐Kyu Choi, Young‐Eun Joo Tags: Original Article Source Type: research

Targeted Delivery of siRNA against Hepatitis B Virus by PreS1 Peptide Molecular Ligand
ConclusionThe results indicated that PreS1‐9Arg may be a potential novel vector to deliver siRNA targeting liver cells.
Source: Hepatology Research - June 28, 2013 Category: Internal Medicine Authors: Wenjuan Huang, Xia Li, Min Yi, Sufen Zhu, Weixian Chen Tags: Original Article Source Type: research