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PT167 RU360 Adsorption in Silica Nanovectors: Potential Use Against Mitochondrial Dysfunction in Heart Failure
Heart failure is the clinical syndrome causing the highest number of adult deaths in industrialized countries, with an annual death rate of 20-40% of the diagnosed cases. There are numerous candidates for heart failure therapy involving regulation of mitochondrial calcium ([Ca2+]m) through the Mitochondrial Calcium Uniporter (MCU), such as the use of Ru360 for inhibition or gene silencing using siRNA. However, their bioavailability is low. Recently, the use of nanovectors as means for drug delivery have been explored given that those could increase the drug bioavailability along with time-programmed drug release.
Source: CVD Prevention and Control - May 31, 2016 Category: Global & Universal Authors: O. Lozano, Y. Oropeza, N. Ornelas, F. Contreras, E. Guerrero-Beltr án, E. Vázquez-Garza, S.E. Cárdenas, G. Torre-Amione, G. García-Rivas Tags: Poster Abstract Source Type: research