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Therapeutics that can shut down harmful genes need a reliable delivery system
(University of Texas at Austin) So far, only a handful of siRNA, or other RNA interference-based therapeutics that can shut down harmful genes to keep viruses from spreading have been approved. Chemical engineering researchers in the Cockrell School of Engineering have created several nanoparticles to help solve the problem of getting the siRNA into the body and guiding it to the target.
Source: EurekAlert! - Medicine and Health - May 17, 2021 Category: International Medicine & Public Health Source Type: news

Green tea compound helps siRNA slip inside cells
(American Chemical Society) Drinking green tea has been linked to health benefits ranging from cardiovascular disease prevention to weight loss. Although many of these claims still need to be verified in the clinic, an antioxidant in green tea called epigallocatechin gallate (EGCG) appears to have beneficial effects in cells and animals. Now, researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells. They report their results in ACS Central Science.
Source: EurekAlert! - Medicine and Health - September 19, 2018 Category: International Medicine & Public Health Source Type: news

Cancer treatment developed at Ben-Gurion U. changes cancer cells into normal ones
(American Associates, Ben-Gurion University of the Negev) " Using the siRNA treatment for several types of cancer in mouse models reprogramed cancer cell metabolism, reduced tumor growth and angiogenesis, reduced tumor invasiveness, and induced cancer stem cell disappearance and cell differentiation, " says BGU Prof. Shoshan-Barmatz.
Source: EurekAlert! - Medicine and Health - May 11, 2018 Category: International Medicine & Public Health Source Type: news

BGRF and SILS scientists analyze viability of shRNA therapy for Huntington's Disease
(Biogerontology Research Foundation) Researchers from the Biogerontology Research Foundation, Department of Molecular Neuroscience at the Swammerdam Institute for Life Sciences at the University of Amsterdam, and the Department of Neurobiology, Care Sciences and Society at the Karolinska Institute announce the publication of a paper in Translational Neurodegeneration, a BioMedCentral journal, titled RNAi mechanisms in Huntington's disease therapy: siRNA versus shRNA.
Source: EurekAlert! - Medicine and Health - December 1, 2017 Category: International Medicine & Public Health Source Type: news