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Specialty: Orthopaedics
Therapy: Chemotherapy
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Total 1 results found since Jan 2013.
Proteomic Identification of 14‐3‐3ϵ as a Linker Protein Between pERK1/2 Inhibition and BIM Upregulation in Human Osteosarcoma Cells
We examined the expression of Bim after silencing 14‐3‐3ϵ using siRNA. The 14‐3‐3ϵ gene silencing resulted in downregulation of Bim expression after PD98059 treatment. These data indicate that 14‐3‐3ϵ is required for Bim expression and that it has an anti‐cancer effect under pERK1/2 inhibition in 143B cells. By playing an essential role upstream of Bim, 14‐3‐3ϵ may potentially be a coadjuvant factor synergizing the effect of pERK1/2 inhibitors in addition to conventional cytotoxic agents for more effective osteosarcoma treatments. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
Source: Journal of Orthopaedic Research - February 17, 2014 Category: Orthopaedics Authors: Kyung Ok Kim, Anny C. Hsu, Heon Goo Lee, Neel Patel, Chandhanarat Chandhanayingyong, Thomas Hickernell, Francis Young‐In Lee Tags: Research Article Source Type: research
