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Single Impact Injury of Vertebral Endplates Without Structural Disruption, Initiates Disc Degeneration Through Piezo1 Mediated Inflammation and Metabolism Dysfunction
Study Design. In vitro experimental study. Objective. To establish an axial impact injury model of intervertebral disc (IVD) and to investigate if a single impact injury without endplate structural disruption could initiate intervertebral disc degeneration (IDD), and what is the roles of Piezo1 in this process. Summary of Background Data. Although IDD process has been confirmed to be associated with structural failures such as endplate fractures, whether a single impact injury of the endplates without structural disruption could initiate IDD remains controversial. Previous studies reported that Piezo1 med...
Source: Spine - February 8, 2022 Category: Orthopaedics Tags: BASIC SCIENCE Source Type: research

Role of Cx43-Mediated NFкB Signaling Pathway in Ossification of Posterior Longitudinal Ligament: An In Vivo and In Vitro Study
Conclusion. Cx43-mediated NFкB (p65) signal played an important role in mechanical stress-induced OPLL by transduction of mechanical signal, while giving rise to the activation of inflammatory response in ligament fibroblasts Level of Evidence: N/A
Source: Spine - November 28, 2017 Category: Orthopaedics Tags: Basic Science Source Type: research

Role of Sirt1 Plays in Nucleus Pulposus Cells and Intervertebral Disc Degeneration
Conclusion. Sirt1 is a protective mediator in IVD degeneration and the expression of Sirt1 decreases in degenerative disc. Activation of Sirt1 works on suppressing cellular senescence, promoting cell proliferation, and restraining the apoptosis of nucleus pulposus cells. Level of Evidence: N/A
Source: Spine - June 27, 2017 Category: Orthopaedics Tags: Basic Science Source Type: research