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Histone deacetylase 4 alters cartilage homeostasis in human osteoarthritis
Conclusions: In this study, our findings suggest that the abnormal expression of HDAC4 in osteoarthritic cartilage might be implicated in promoting catabolic activity of chondrocyte, which is associated with OA pathogenesis. Thus, our findings give a new insight into the mechanism of articular cartilage damage, and indicate that HDAC4 might be a potential target for the therapeutic interventions of OA.
Source: BMC Musculoskeletal Disorders - December 17, 2014 Category: Orthopaedics Authors: Jingwei LuYe SunQiting GeHuajian TengQing Jiang Source Type: research

Connexin43 enhances the expression of osteoarthritis-associated genes in synovial fibroblasts in culture
Conclusions: Increasing or decreasing Cx43 expression alone was sufficient to alter the levels of catabolic and inflammatory genes expressed by synovial cells. The NFkappaB cascade mediated the effect of Cx43 on the expression of a subset of these OA-associated genes. As such, Cx43 may be involved in joint pathology during OA, and targeting Cx43 expression or function may be a viable therapeutic strategy to attenuate the catabolic and inflammatory environment of the joint during OA.
Source: BMC Musculoskeletal Disorders - December 11, 2014 Category: Orthopaedics Authors: Aditi GuptaCorinne NigerAtum BuoEric EidelmanRichard ChenJoseph Stains Source Type: research

Effects of hyperbaric oxygen on the osteogenic differentiation of mesenchymal stem cells
Conclusion: HBO treatment increased osteogenic differentiation of MSCs via regulating Wnt processing, secretion, and signaling.
Source: BMC Musculoskeletal Disorders - February 25, 2014 Category: Orthopaedics Authors: Song-Shu LinSteve UengChi-Chien NiuLi-Jen YuanChuen-Yung YangWen-Jer ChenMel LeeJan-Kan Chen Source Type: research