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Specialty: Opthalmology
Drug: Insulin
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Total 2 results found since Jan 2013.
Pioglitazone Restores IGFBP-3 Levels Through DNA PK in Retinal Endothelial Cells Cultured in Hyperglycemic Conditions Retinal Cell Biology
Conclusions.
Our findings suggest that pioglitazone mediates regulation of IGFBP-3 via activation of PKA/DNA PK pathway in hyperglycemic retinal endothelial cells.
Source: Investigative Ophthalmology - January 13, 2015 Category: Opthalmology Authors: Thakran, S., Zhang, Q., Morales-Tirado, V., Steinle, J. J. Tags: Retinal Cell Biology Source Type: research
DNA-PK Phosphorylation of IGFBP-3 Is Required to Prevent Apoptosis in Retinal Endothelial Cells Cultured in High Glucose Retina Cell Biology
Conclusions.
Our findings suggest Compound 49b induces DNA-PK levels through PKA activity. DNA-PK is required for Compound 49b–induced IGFBP-3 expression, leading to inhibition of REC cell death.
Source: Investigative Ophthalmology - April 30, 2013 Category: Opthalmology Authors: Zhang, Q., Steinle, J. J. Tags: Retina Cell Biology Source Type: research
