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Immunoglobulin A promotes IL-6 and IL-8 production, proliferation, and migration by the human bronchial smooth muscle cells
Cell Immunol. 2022 Sep 16;381:104612. doi: 10.1016/j.cellimm.2022.104612. Online ahead of print.ABSTRACTImmunoglobulin A (IgA) is important in biological defense, mainly in the mucosal area, and plays pathogenic roles in various diseases by activating both inflammatory and structural cells. The current study aimed to validate the effects of IgA on the human bronchial smooth muscle cell (BSMC), which plays a major role in airway inflammation and remodeling. Serum IgA induced interleukin (IL)-6 and IL-8 production at both mRNA and protein levels, and enhanced cell proliferation and migration by the BSMCs. The synthetic pheno...
Source: Cellular Immunology - September 21, 2022 Category: Allergy & Immunology Authors: Sahoko Imoto Maho Suzukawa Kazufumi Takada Shizuka Watanabe Sayaka Igarashi Masashi Kitani Takahide Nagase Ken Ohta Source Type: research

Rubicon promotes the M2 polarization of Kupffer cells via LC3-associated phagocytosis-mediated clearance to improve liver transplantation
CONCLUSIONS: Rubicon-mediated LAP promotes the clearance capability and M2 polarization of KCs via PUFA-dependent PPARγ activation to improve LT.PMID:35700602 | DOI:10.1016/j.cellimm.2022.104556
Source: Cellular Immunology - June 14, 2022 Category: Allergy & Immunology Authors: Yajun Chen Yiping He Xinyi Wu Xuesong Xu Junhua Gong Yong Chen Jianping Gong Source Type: research

Overexpression of DAPK1-mediated inhibition of IKKbeta/CSN5/PD-L1 axis enhances natural killer cell killing ability and inhibits tumor immune evasion in gastric cancer
Cell Immunol. 2021 Dec 10;372:104469. doi: 10.1016/j.cellimm.2021.104469. Online ahead of print.ABSTRACTGastric cancer (GC) originates from the stomach and is a prevalent human malignancy. Dysfunction of death associated protein kinase 1 (DAPK1) has been identified as a major regulator involved in the development and progression of GC. However, there's limited data regarding the regulatory mechanism of GC. Herein, we investigated role of DAPK1 in natural killer (NK) cell killing ability and immune evasion of GC cells and mediated pathway. Samples from GC-related gene expression profile and clinical samples from 67 patients...
Source: Cellular Immunology - February 3, 2022 Category: Allergy & Immunology Authors: Zhiyuan Guo Cheng Zhou Linsen Zhou Zhiqiang Wang Xinguo Zhu Xiangming Mu Source Type: research

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