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Hyperglycemia Suppresses RANKL-Induced Osteoclast Differentiation through LXR β Expression in RAW264.7 Cells.
Hyperglycemia Suppresses RANKL-Induced Osteoclast Differentiation through LXRβ Expression in RAW264.7 Cells. J Nutr Sci Vitaminol (Tokyo). 2017;63(1):28-34 Authors: Tanaka T, Takei Y, Zaima N, Moriyama T, Yamanouchi D Abstract There have been reports that hyperglycemia suppresses osteoclast (OCL) differentiation, although the underlying mechanism is poorly understood. Here we demonstrated that high glucose suppresses OCL differentiation through activation of liver X receptor (LXR) β, a recently reported glucose-sensing nuclear receptor. The effect of hyperglycemia on osteoclastogenesis was tested in ...
Source: Journal of Nutritional Science and Vitaminology - April 4, 2017 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research