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Glycyrrhiza Uralensis and Semilicoisoflavone B Reduce A β Secretion by Increasing PPARγ Expression and Inhibiting STAT3 Phosphorylation to Inhibit BACE1 Expression
Conclusion: These findings indicate that GUE and SB may function as PPARγ agonists, thereby inhibiting BACE1 expression and ultimately reducing the secretion of Aβ.This article is protected by copyright. All rights reserved
Source: Nahrung / Food - November 1, 2017 Category: Nutrition Authors: Ming ‐Yao Gu, Yoon Sun Chun, Dong Zhao, Ryu Shi Yong, Hyun Ok Yang Tags: Research Article Source Type: research

Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway
Publication date: April 2016 Source:Journal of Functional Foods, Volume 22 Author(s): Junjun Chen, Xueyang Deng, Ning Liu, Min Li, Baolin Liu, Qiang Fu, Rong Qu, Shiping Ma Quercetin, a natural flavonoid abundantly found in onions, apples, tea, berries, cauliflower, and red wine, has been demonstrated to exert beneficial effect on Alzheimer's disease. We aimed to investigate its AMPK activity on hyperphosphorylation of tau and explore the underlying mechanism associated with Endoplasmic reticulum (ER) stress. Quercetin and quercetin-3-O-glucuronide suppressed ER stress with decreased phosphorylation of IRE1α and...
Source: Journal of Functional Foods - February 24, 2016 Category: Nutrition Source Type: research