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Specialty: Nuclear Medicine
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Total 17 results found since Jan 2013.
The preclinical characterization of 18FhGTS13 for imaging of xC- transporter activity
Conclusion: [18F]hGTS13 is a novel radiotracer for measuring xC- transporter activity. It showed high and specific uptake in cell assays with A549 and H460 cells. [18F]hGTS13 showed significantly lower uptake in activated T cells compared to [18F]FSPG. PET/CT imaging of [18F]hGTS13 in H460 tumor bearing rats revealed significantly higher tumor uptake than [18F]FSPG.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Beinat, C., Gowrishanker, G., Shen, B., Alam, I., Robinson, E., Ilovich, O., Koglin, N., Schmitt-Willich, H., Berndt, M., Mueller, A., Zerna, M., Srinivasan, A., Gambhir, S. Tags: Preclinical Probes for Oncology III Source Type: research
P53 mediates the stimulation of mitochondrial reactive oxygen species and suppression of 18F-FDG uptake and glycolysis in isoprenaline-treated H9C2 cardiomyocytes
Conclusions: These findings demonstrate that ISO treatment decreases cardiomyocyte 18F-FDG uptake by downregulating glycolytic flux and further reveals that ROS-p53 signaling plays a critical role in this metabolic response.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Lee, J. H., Kim, D. H., Kim, M., Cho, Y. S., Jung, K.-H., LEE, K.-H. Tags: Cardiovascular Basic Science Source Type: research
