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Role of Prion protein in premature senescence of human fibroblasts
Publication date: Available online 8 August 2017 Source:Mechanisms of Ageing and Development Author(s): Emmanuelle Boilan, Virginie Winant, Elise Dumortier, Benaissa ElMoualij, Pascale Quatresooz, Heinz D. Osiewacz, Florence Debacq-Chainiaux, Olivier Toussaint Prion protein (PrP) is essentially known for its capacity to induce neurodegenerative prion diseases in mammals caused by a conformational change in its normal cellular isoform (PrPC) into an infectious and disease-associated misfolded form, called scrapie isoform (PrPSc). Although its sequence is highly conserved, less information is available on its physiological ...
Source: Mechanisms of Ageing and Development - August 9, 2017 Category: Geriatrics Source Type: research
