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Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility
Publication date: Available online 18 June 2018Source: Mechanisms of Ageing and DevelopmentAuthor(s): Valérie Haydont, Véronique Neiveyans, Hélène Zucchi, Nicolas O. Fortunel, Daniel AsselineauAbstractDeciphering the characteristics of dermal fibroblasts is critical to further understand skin ageing. We have conducted a genome-wide transcriptomic characterization of papillary (Fp) and reticular (Fr) fibroblasts extracted from human skin samples corresponding to younger and older adult ages. From this screen, biomarkers suitable for the assessment of chronological ageing were identified, and extrapolated to the context ...
Source: Mechanisms of Ageing and Development - July 10, 2018 Category: Geriatrics Source Type: research

OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes
Publication date: Available online 2 November 2017 Source:Mechanisms of Ageing and Development Author(s): Ionela-Mariana Nagelreiter, Masomeh Parvardeh, Marie-Sophie Narzt, Lucian Beer, Christopher Kremslehner, Ximena Maria Muresan, Johannes Grillari, Christos C. Zouboulis, Erwin Tschachler, Florian Gruber Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-enzymatically or enzymatically by ultraviolet light, the major extrinsic skin aging factor. OxPL regulate cytoprotective, immunological and metabolic adaptation of the skin to...
Source: Mechanisms of Ageing and Development - December 11, 2017 Category: Geriatrics Source Type: research

Role of Prion protein in premature senescence of human fibroblasts
Publication date: Available online 8 August 2017 Source:Mechanisms of Ageing and Development Author(s): Emmanuelle Boilan, Virginie Winant, Elise Dumortier, Benaissa ElMoualij, Pascale Quatresooz, Heinz D. Osiewacz, Florence Debacq-Chainiaux, Olivier Toussaint Prion protein (PrP) is essentially known for its capacity to induce neurodegenerative prion diseases in mammals caused by a conformational change in its normal cellular isoform (PrPC) into an infectious and disease-associated misfolded form, called scrapie isoform (PrPSc). Although its sequence is highly conserved, less information is available on its physiological ...
Source: Mechanisms of Ageing and Development - August 9, 2017 Category: Geriatrics Source Type: research

Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging
We reported that regulation of retinoid, especially atRA and 9-cis RA, responsive StAR transcription is largely mediated by an LXR-RXR/RAR heterodimeric motif in the mouse StAR promoter. Herein we demonstrate that retinoids are capable of enhancing StAR protein, P-StAR, and steroid production, in granulosa, adrenocortical, glial, and epidermal cells. Whereas transient expression of RARα and RXRα enhanced 9-cis RA-treated StAR gene transcription, silencing of RXRα with siRNA, decreased StAR and steroid levels. An oligonucleotide probe encompassing an LXR-RXR/RAR motif bound to adrenocortical and epidermal keratinocyte NE...
Source: Mechanisms of Ageing and Development - August 22, 2015 Category: Geriatrics Source Type: research

p16INK4A mediates age-related changes in mesenchymal stem cells derived from human dental pulp through the DNA damage and stress response
Publication date: November–December 2014 Source:Mechanisms of Ageing and Development, Volumes 141–142 Author(s): Xingmei Feng , Jing Xing , Guijuan Feng , Dan Huang , Xiaohui Lu , Suzhe Liu , Wei Tan , Liren Li , Zhifeng Gu Mesenchymal stem cells derived from human dental pulp (DP-MSCs) are characterized by self-renewal and multi-lineage differentiation, which play important roles in regenerative medicine. Autologous transfers, as non-immunogenic, constitute the safest approach in cellular transplantations. However, their use may be limited by age-related changes. In the study, we compared DP-MSCs isolated from human...
Source: Mechanisms of Ageing and Development - November 3, 2014 Category: Geriatrics Source Type: research