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Specialty: Geriatrics
Drug: Metformin
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Changes in AMPK activity induces cellular senescence in human dental follicle cells
This study examined the role of AMPK in inducing senescence in DFCs. During the induction of cellular senescence, AMPK activity was impaired, suggesting a negative impact on senescence induction. In line with this assumption, cellular senescence was induced upon inhibition of AMPK with a specific siRNA. In addition, after this inhibition, autophagy was also inhibited. Moreover, specific inhibition of autophagy promoted cellular senescence. However, inducers of AMPK such as metformin or AICAR surprisingly increased senescence in DFCs. Interestingly, autophagy was impaired after long-term induction of AMPK with AICAR and met...
Source: Experimental Gerontology - December 23, 2022 Category: Geriatrics Authors: Christian Morsczeck Anja Reck Torsten E Reichert Source Type: research
