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Specialty: Geriatrics
Condition: Alzheimer's
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Total 1 results found since Jan 2013.
Aging induces abnormal accumulation of A β in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain
Neurobiol Aging. 2021 Jul 5;106:268-281. doi: 10.1016/j.neurobiolaging.2021.06.022. Online ahead of print.ABSTRACTAβ metabolism in the brain is mediated by endocytosis, one part of the intracellular membrane trafficking system. We previously showed that aging attenuates the interaction of dynein with dynactin, which disrupts the endosomal/lysosomal trafficking pathway involved in Aβ metabolism, resulting in intracellular accumulation of Aβ. Several studies have shown that in Alzheimer's disease (AD), intraneuronal accumulation of Aβ precedes extracellular Aβ depositions. However, it is unclear what accounts for this t...
Source: Neurobiology of Aging - July 30, 2021 Category: Geriatrics Authors: Shingo Koinuma Nobuhiro Shimozawa Yasuhiro Yasutomi Nobuyuki Kimura Source Type: research
