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Experimental Study on 1,25(OH)2D3 Amelioration of Oral Lichen Planus through Regulating NF ‐κB Signaling Pathway
ConclusionThese results suggest that 1,25(OH)2D3 plays an anti‐inflammatory role in OLP by mediating NF‐κB signaling pathway but not AP‐1 signaling pathway with a VDR‐dependent manner, predicting vitamin D supplement may be a potential strategy for the OLP management.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - February 22, 2017 Category: ENT & OMF Authors: Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang Tags: Original Article Source Type: research

Sprouty2 Inhibition Promotes Proliferation and Migration of Periodontal Ligament Cells
ConclusionSpry2 combined with bFGF and EGF stimulation reduced PDL cell migration and proliferation with inducing osteoblastic differentiation. These in vitro findings may provide a molecular basis for novel therapeutic approaches for establishing periodontal tissue regeneration.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - September 1, 2015 Category: ENT & OMF Authors: Urara Tanaka, Terukazu Sanui, Takao Fukuda, Kyosuke Toyoda, Takaharu Taketomi, Ryo Atomura, Kensuke Yamamichi, Hidefumi Maeda, Fusanori Nishimura Tags: Original Article Source Type: research

IL‐1β‐induced matrix metalloproteinase‐3 regulates cell proliferation in rat dental pulp cells
ConclusionsInterleukin‐1β induces matrix metalloproteinase‐3–regulated cell proliferation and suppresses apoptosis in dental pulp cells.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - December 12, 2013 Category: ENT & OMF Authors: Nobuaki Ozeki, Hideyuki Yamaguchi, Taiki Hiyama, Rie Kawai, Kazuhiko Nakata, Makio Mogi, Hiroshi Nakamura Tags: Original Article Source Type: research

The in vitro apoptotic effects of A248 and A1659, newly synthetic histone deacetylase inhibitors in oral cancer cells
ConclusionThese results suggest that A248 and A1659, two new HDAC inhibitors, may be attractive therapeutic drug candidates for targeting Sp1 in human oral cancer cells.
Source: Oral Diseases - July 14, 2013 Category: ENT & OMF Authors: J‐A Shin, G Han, S‐K Park, K Lee, H‐J Kim, S‐D Cho, HM Kim Tags: Original Article Source Type: research

The in vitro apoptotic effects of A248 and A1659, newly synthetic HDAC inhibitors in oral cancer cells
ConclusionThese results suggest that A248 and A1659, two new HDAC inhibitors may be attractive therapeutic drug candidates for targeting Sp1 in human oral cancer cells.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - July 1, 2013 Category: ENT & OMF Authors: Ji‐Ae Shin, Gyoonhee Han, Song‐Kyu Park, Kiho Lee, Hyun‐Jung Kim, Sung‐Dae Cho, Hwan Mook Kim Tags: Original Article Source Type: research

Apoptotic effect of dibenzylideneacetone on oral cancer cells via modulation of specificity protein 1 and Bax
ConclusionThese findings suggest that DBA may be a potential anticancer drug candidate to induce apoptosis through down‐regulation of Sp1 in human oral cancer.
Source: Oral Diseases - January 11, 2013 Category: ENT & OMF Authors: H‐J Yu, J‐A Shin, J‐S Nam, B S Kang, S‐D Cho Tags: Original Article Source Type: research