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Stimulus-responsive hybrid nanoparticles based on multiple lipids for the co-delivery of doxorubicin and Sphk2-siRNA and breast cancer therapy
Food Chem Toxicol. 2022 Nov 28:113532. doi: 10.1016/j.fct.2022.113532. Online ahead of print.NO ABSTRACTPMID:36455683 | DOI:10.1016/j.fct.2022.113532
Source: Food and Chemical Toxicology - December 1, 2022 Category: Food Science Authors: Jinying Liang Shiqi Guo Mengxin Bai Mengying Huang Yupeng Qu Ying Zhao Yu Song Source Type: research

Suppression of GOLM1 by EGCG through HGF/HGFR/AKT/GSK-3 β/β-catenin/c-Myc signaling pathway inhibits cell migration of MDA-MB-231
Food Chem Toxicol. 2021 Sep 15:112574. doi: 10.1016/j.fct.2021.112574. Online ahead of print.ABSTRACTGolgi Membrane Protein 1 (GOLM1) has been identified as a prime target for cancer therapy because it overexpresses in many solid tumors, increases tumor growth and metastasis and leads to unfavorable survival. Though various approaches including siRNA interference and antibody targeting have been attempted, GOLM1 has remained an un-targetable molecule because of its mainly intracellular location and the lack of domains that could possibly be interfered with by small molecules. Numerous natural anti-tumoral plant substances ...
Source: Food and Chemical Toxicology - September 18, 2021 Category: Food Science Authors: Ling Xie Jun Yi Yongjia Song Mengyao Zhao Liqiang Fan Liming Zhao Source Type: research

Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress.
Abstract Prolonged endoplasmic reticulum (ER) stress may activate apoptotic pathways in cancer cells. It is suggested that ER stress has the potential of enhancing tumor death in cancer therapy. Galangin, a flavonol derived from Alpinia officinarum Hance, has been shown to suppress the proliferation of hepatocellular carcinoma cells (HCC). The aim of this study was to determine whether galangin was able to induce ER stress in HepG2, Hep3B and PLC/PRF/5 cells. The proliferation of HCC was tested by MTT method. Intracellular Ca(2+) levels were measured with Fluo3-AM.The proteins levels of GRP94, GRP78 and CHOP were ...
Source: Food and Chemical Toxicology - October 22, 2013 Category: Food Science Authors: Su L, Chen X, Wu J, Lin B, Zhang H, Lan L, Luo H Tags: Food Chem Toxicol Source Type: research