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Specialty: Food Science
Source: Food and Chemical Toxicology
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Total 46 results found since Jan 2013.
DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway
In this study, HepG2 cells were treated with 0.0625, 0.125, 0.25, 0.5 and 1 mM Dibutyl phthalate (DBP) for 48 h to investigate mitochondrial toxicity. The results showed that DBP caused mitochondrial damage, autophagy, apoptosis and necroptosis; Transcriptomics analysis identified that MAPK and PI3K were significant factors in the cytotoxic changes induced by DBP; N-Acetyl-L-cysteine (NAC), SIRT1 activator, ERK inhibitor, p38 inhibitor and ERK siRNA treatments counteracted the changes of SIRT1/PGC-1α and Nrf2 pathway-related proteins, autophagy and necroptotic apoptosis proteins induced by DBP. While PI3K and Nrf2 inhibit...
Source: Food and Chemical Toxicology - April 14, 2023 Category: Food Science Authors: Huan Liu Linjing Xu Lizi Zhou Wenna Han Zhongyi Li Chunhong Liu Source Type: research
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin
In this study, however, autophagy and mTOR were found to be inhibited simultaneously by curcumin treatments, and both of them played an important role in the effect of curcumin on suppressing the growth of A549 cells. Tunicamycin (TM), the activator of Endoplasmic Reticulum (ER) stress, increased both autophagy and AKT/mTOR, while curcumin could significantly decrease TM-induced autophagy and AKT/mTOR. Furthermore, curcumin could inhibit TM-induced aerobic glycolysis in A549 cells, and decrease the level of cycle-related and migration-related proteins. Blocking activating transcription factor 4 (ATF4) by siRNA strongly red...
Source: Food and Chemical Toxicology - January 14, 2023 Category: Food Science Authors: Jie Yang None Hasenbilige Shibo Bao Shengxiang Luo Liping Jiang Qiujuan Li Ying Kong Jun Cao Source Type: research
Hyperoside attenuates Cd-induced kidney injury via inhibiting NLRP3 inflammasome activation and ROS/MAPK/NF- κB signaling pathway in vivo and in vitro
This study aimed to research the effects and related mechanism of HYP on Cd-induced kidney damage. Wide-type and NLRP3-/- mice were used to determine the role of NLRP3 inflammasome in Cd-induced renal dysfunction. Female C57BL/6 were treated with Cd (50 m,g/L) and HYP (25, 50 mg/kg) for 12 weeks. In vitro experiments, the human renal proximal-tubule epithelial cells (RPTEC/TERT1) were pretreated with HYP (50-200 μM) before exposure to Cd. NLRP3 deficiency attenuated Cd-induced NLRP3 activation, inflammation and kidney injury in mice. HYP treatment significantly alleviated Cd-induced kidney injury by decreasing indexes of ...
Source: Food and Chemical Toxicology - January 7, 2023 Category: Food Science Authors: Ziyin Li Weizuo Liao Xinxin Yin Lili Liu Zhiqiang Zhao Xiaodan Lu Feifei Xu Xiuqin Lin Yingsi Chen Jia Song Zhini He Qinzhi Wei Weiliang Wu Yongning Wu Xingfen Yang Source Type: research
Lonp1 and Sig-1R contribute to the counteraction of ursolic acid against ochratoxin A-induced mitochondrial apoptosis
In conclusion, through mutual promotion between Lonp1 and Sig-1R, UA could effectively relieve OTA-induced apoptosis in vitro and break the vicious cycle between oxidative stress and ERS, which activated the mitochondrial apoptosis pathway.PMID:36587836 | DOI:10.1016/j.fct.2022.113592
Source: Food and Chemical Toxicology - January 1, 2023 Category: Food Science Authors: Qipeng Zhang Wenying Chen Boyang Zhang Yiwen Zhang Yuqing Xiao Yichen An Lingyun Han Huiqiong Deng Song Yao Hongwei Wang Xiao Li Shen Source Type: research
Stimulus-responsive hybrid nanoparticles based on multiple lipids for the co-delivery of doxorubicin and Sphk2-siRNA and breast cancer therapy
Food Chem Toxicol. 2022 Nov 28:113532. doi: 10.1016/j.fct.2022.113532. Online ahead of print.NO ABSTRACTPMID:36455683 | DOI:10.1016/j.fct.2022.113532
Source: Food and Chemical Toxicology - December 1, 2022 Category: Food Science Authors: Jinying Liang Shiqi Guo Mengxin Bai Mengying Huang Yupeng Qu Ying Zhao Yu Song Source Type: research
Fumonisin B < sub > 1 < /sub > induced intestinal epithelial barrier damage through endoplasmic reticulum stress triggered by the ceramide synthase 2 depletion
In this study, we found that FB1 inhibited cell viability, and promoted the severe release of lactate dehydrogenase. Meantime, FB1 destroyed the intestinal physical barrier by reducing the expressions of tight junctions. And FB1 induced excessive production of cytokines like tumor necrosis factor-α, resulting in damage to the intestinal immunological barrier. Furthermore, we observed that FB1 preferentially inhibited the expressions of ceramide synthase 2 (CerS2) and upregulated the expression of endoplasmic reticulum (ER) stress markers. The siRNA-mediated knockdown of CerS2 and CerS2 overexpression proved that CerS2 dep...
Source: Food and Chemical Toxicology - July 1, 2022 Category: Food Science Authors: Mengcong Li Shuhui Liu Lei Tan Yan Luo Zhangshan Gao Jiwen Liu Yuting Wu Wentao Fan Sarah DeSaeger Suquan Song Source Type: research
Deoxynivalenol enhances estrogen receptor alpha-induced signaling by ligand-independent transactivation
Food Chem Toxicol. 2022 May 16:113127. doi: 10.1016/j.fct.2022.113127. Online ahead of print.ABSTRACTDeoxynivalenol (DON), which is one of the prevalent mycotoxins in food and feeds, exerts adverse effects on animal and human health. These effects are mainly associated with its ribotoxic properties, although few studies suggest the involvement of other mechanisms of action. To assess the ability of DON to disrupt estrogen signaling, we conducted an in vitro study using MCF-7 and MDA-MB-231 cells. After 72h, DON reduced cell viability in both cell lines, thus highlighting its well-known cytotoxic effect. However, after 6h, ...
Source: Food and Chemical Toxicology - May 19, 2022 Category: Food Science Authors: M Drouault C Delalande H Boura ïma-Lelong V Seguin D Garon V Hanoux Source Type: research
Chaperon-mediated autophagy can regulate diquat-induced apoptosis by inhibiting α-synuclein accumulation cooperatively with macroautophagy
In this study, we explored the role of CMA in diquat (DQ)-induced α-synucleinopathy and characterized the relationship between CMA and macroautophagy in the clearance of pathologic α-synuclein for the prevention of DQ neurotoxicity. DQ was cytotoxic to SH-SY5Y cells in a concentration-dependent manner, as shown by decreased cell viability and increased cytotoxicity. DQ treatment was also found to induce autophagy such as CMA and macroautophagy by monitoring the expression of Lamp2A and microtubule-associated protein 1A/1B light chain 3B (LC3-II) respectively. Following DQ treatment, SH-SY5Y cells were found to have induc...
Source: Food and Chemical Toxicology - December 1, 2021 Category: Food Science Authors: Hong Ju Kim Hyun Chul Koh Source Type: research
